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2017 ; 8
(Suppl 1
): S57-S65
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Butterfly Tumor of the Corpus Callosum: Clinical Characteristics, Diagnosis, and
Survival Analysis
#MMPMID28936073
Tunthanathip T
; Ratanalert S
; Sae-Heng S
; Oearsakul T
J Neurosci Rural Pract
2017[Aug]; 8
(Suppl 1
): S57-S65
PMID28936073
show ga
BACKGROUND: The pathologies implicate the bilateral corpus callosum that builds
the butterfly pattern on axial view. These tumors have seldom been investigated
for both clinical manifestations and outcome. OBJECTIVE: The objective of this
study was to describe the clinical characteristics and outcomes of the butterfly
tumor and to identify the predictive factors associated with survival outcome.
METHODS: A retrospective study of 50 butterfly tumor was conducted between 2003
and 2016. The clinical characteristics, imaging, and outcome were assessed for
the purpose of descriptive analysis. Using the Kaplan-Meier method, the median
overall survival of the butterfly tumor was determined. Furthermore, the Cox
proportional hazard regression was the estimated hazard ratio for death. RESULTS:
Diffuse large B-cell lymphoma was common of butterfly lesions. The mortality rate
was 78% and overall median survival time was 16.03 months (95% confidence
interval: 14.0-19.8). Using Cox proportional hazards regression, the independent
prognostic factors were Karnofsky Performance Status score ?70, splenium
involvement, and butterfly glioblastoma. CONCLUSIONS: The butterfly tumor is a
poor prognostic disease compared with each histology subgroup. Further molecular
investigation is preferable to explore genetic variations associated with these
tumors.