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10.1038/s41598-017-12011-4 http://scihub22266oqcxt.onion/10.1038/s41598-017-12011-4 C5601951!5601951 !28916770     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28916770 &cmd=llinks): Failed to open stream: HTTP request failed! 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Changes in CD73, CD39 and CD26 expression on T-lymphocytes of ANCA-associated vasculitis patients suggest impairment in adenosine generation and turn-over |pdf=|usr=}}{{28916770 }} gab.com Text Changes in CD73, CD39 and CD26 expression on T-lymphocytes of ANCA-associated vasculitis patients suggest impairment in adenosine generation and turn-over JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28916770 #FOAvip Extracellular adenosine, generated via the concerted action of CD39 and CD73, contributes to T-cell differentiation and function. Adenosine concentrations are furthermore influenced by adenosine deaminase binding protein CD26. Because aberrant T-cell phenotypes had been reported in anti-neutrophil cytoplasmic auto-antibody (ANCA)-associated vasculitis (AAV) patients, an impaired expression of these molecules on T-cells of AAV patients was hypothesized in the present study. While in AAV patients (n?=?29) CD26 was increased on CD4(+) lymphocytes, CD39 and CD73 were generally reduced on patients' T-cells. In CD4(+) cells significant differences in CD73 expression were confined to memory CD45RA(-) cells, while in CD4(-) lymphocytes differences were significant in both naïve CD45RA(+) and memory CD45RA(-) cells. The percentage of CD4(-)CD73(+) cells correlated with micro-RNA (miR)-31 expression, a putative regulator of factor inhibiting hypoxia-inducible factor 1 alpha (FIH-1), inversely with serum C-reactive protein (CRP) and positively with estimated glomerular filtration rate (eGFR). No correlation with disease activity, duration, and ANCA profile was found. It remains to be assessed if a decreased CD73 and CD39 expression underlies functional impairment of lymphocytes in AAV patients. Likewise, the relations between frequencies of CD4(-)CD73(+) cells and serum CRP or eGFR require further functional elucidation. Twit Text FOAVip Changes in CD73, CD39 and CD26 expression on T-lymphocytes of ANCA-associated vasculitis patients suggest impairment in adenosine generation and turn-over ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28916770 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28916770 #FOAvip English Wikipedia <ref>{{Cite pmid|28916770 }}</ref> Changes in CD73, CD39 and CD26 expression on T-lymphocytes of ANCA-associated vasculitis patients suggest impairment in adenosine generation and turn-over #MMPMID28916770 Kling L ; Benck U ; Breedijk A ; Leikeim L ; Heitzmann M ; Porubsky S ; Krämer BK ; Yard BA ; Kälsch AI Sci Rep 2017[Sep]; 7 (1 ): 11683 PMID28916770 show ga Extracellular adenosine, generated via the concerted action of CD39 and CD73, contributes to T-cell differentiation and function. Adenosine concentrations are furthermore influenced by adenosine deaminase binding protein CD26. Because aberrant T-cell phenotypes had been reported in anti-neutrophil cytoplasmic auto-antibody (ANCA)-associated vasculitis (AAV) patients, an impaired expression of these molecules on T-cells of AAV patients was hypothesized in the present study. While in AAV patients (n?=?29) CD26 was increased on CD4(+) lymphocytes, CD39 and CD73 were generally reduced on patients' T-cells. In CD4(+) cells significant differences in CD73 expression were confined to memory CD45RA(-) cells, while in CD4(-) lymphocytes differences were significant in both naïve CD45RA(+) and memory CD45RA(-) cells. The percentage of CD4(-)CD73(+) cells correlated with micro-RNA (miR)-31 expression, a putative regulator of factor inhibiting hypoxia-inducible factor 1 alpha (FIH-1), inversely with serum C-reactive protein (CRP) and positively with estimated glomerular filtration rate (eGFR). No correlation with disease activity, duration, and ANCA profile was found. It remains to be assessed if a decreased CD73 and CD39 expression underlies functional impairment of lymphocytes in AAV patients. Likewise, the relations between frequencies of CD4(-)CD73(+) cells and serum CRP or eGFR require further functional elucidation. |5'-Nucleotidase [MESH] |Adenosine/*metabolism [MESH] |Adolescent [MESH] |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*pathology [MESH] |Apyrase/*analysis [MESH] |C-Reactive Protein/analysis [MESH] |Dipeptidyl Peptidase 4/*analysis [MESH] |Female [MESH] |GPI-Linked Proteins [MESH] |Glomerular Filtration Rate [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH] |T-Lymphocytes/*pathology [MESH]Changes in CD73, CD39 and CD26 expression on T-lymphocytes of ANCA-ass(epmc).pdf DeepDyve Pubget Overpricing