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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Oncotarget
2017 ; 8
(35
): 59867-59877
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Efficacy and safety of traditional chemotherapies for patients with ovarian
neoplasm: a network meta-analysis
#MMPMID28938689
Yang L
; Guo G
; Sun L
; Li C
; Zhang H
Oncotarget
2017[Aug]; 8
(35
): 59867-59877
PMID28938689
show ga
BACKGROUND: Ovarian neoplasm is a kind of high risky cancer among female. This
paper assessed the efficacy and safety of twelve therapies and figured out the
superior chemotherapeutic drug for ovarian cancer through network meta-analysis
(NMA). METHOD: Eligible randomized controlled trials (RCTs) were retrieved from
electronic databases. Primary outcomes concerning efficacy, overall survival (OS)
and progression-free survival (PFS), were presented as hazard ratio (HR) and the
associated 95% credible interval(CrI), while outcomes concerning safety were
assessed by odds ratio (OR) and the corresponding 95% CrI. Surface under the
cumulative ranking curve (SUCRA) was calculated under each survival and safety
outcome in order to show the rankings of tested therapies. RESULT: Electronic
databases such as PubMed and Embase were searched to finally obtain 19 eligible
studies of 16290 patients. In accordance of primary outcomes, when it came to 3-y
PFS, paclitaxel/epirubicin/carboplatin (Pa/E/Ca) and pegylated liposomal
doxorubicin/ paclitaxel/ carboplatin (PLD/Pa/Ca) were preferred compared to
carboplatin (Ca) (HR= 0.80, 95% CrI= 0.67-0.96; HR= 0.83, 95% CrI= 0.69-0.99).
According to 5y-PFS, Pa/E/Ca was notably better than Ca (HR= 0.80, 95% CrI=
0.65-0.99). As to adverse effects, Ca was superior to Pa/E/Ca in neuropathy
(HR=0.05, 95% CrI=0.02-0.19). Pa/E/Ca showed high rankings in 3y-PFS
(SUCRA=0.749), 5y-OS (SUCRA=0.738) and 5y-PFS (SUCRA=0.798) while (PLD/Pa/Ca) in
3y-OS (SUCRA=0.737), 5y-OS (SUCRA=0.687) and 5y-PFS (SUCRA=0.712). Besides,
Pa/E/Ca ranked the third with a SUCRA of 0.661 in neutropenia. CONCLUSION:
PLD/Pa/Ca, PLD/Ca and Pa/E/Ca are highly recommended as potential therapeutically
choices for patients with ovarian cancer. But considering the lack of safety data
for PLD/Pa/Ca, this intervention should be taken with caution.
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