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2017 ; 8
(35
): 59748-59756
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gab.com Text
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The response of the Oxford classification to steroid in IgA nephropathy: a
systematic review and meta-analysis
#MMPMID28938678
Yang P
; Chen X
; Zeng L
; Hao H
; Xu G
Oncotarget
2017[Aug]; 8
(35
): 59748-59756
PMID28938678
show ga
BACKGROUND: The present review is aimed to evaluate the correlation between
pathological features and the response to steroid in the patients with IgA
nephropathy according to the Oxford classification, mesangial hypercellularity
(M), endocapillary hypercellularity (E), segmental glomerulosclerosis (S),
tubular atrophy and interstitial fibrosis (T). METHODS: We searched Chinese
Biomedical Database, EMBASE, Cochrane Library, PubMed and MEDLINE with all
spellings of "IgA nephropathy", "Oxford Classification", and "steroid". RESULTS:
5 studies with 637 patients were eligible for inclusion. The analysis showed that
M1, S1, and T1/2 was strongly associated with the prediction to steroid
resistance when compared with M0 [odds ratio (OR) 1.89, 95% confidence interval
(CI) 1.01 - 3.56, P < 0.05], S0 (OR 2.24, 95% CI 0.99 - 5.08, P = 0.05) and T0
(OR 2.16, 95% CI 1.29 - 3.63, P = 0.004) respectively. There is no difference in
steroid sensitivity between E0 and E1 (P = 0.55). The pooled OR of steroid
resistance for E1 versus T1/2 is 0.50 (P = 0.04). CONCLUSION: IgA nephropathy
patients with serious pathological changes (M1, S1, and T1/2) were more resistant
to steroid than slight ones (M0, S0, and T0), and E1 is better response to
steroid therapy than T1/2.