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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Oncotarget
2017 ; 8
(35
): 59638-59647
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lncRNAs as prognostic molecular biomarkers in hepatocellular carcinoma: a
systematic review and meta-analysis
#MMPMID28938667
Zheng C
; Liu X
; Chen L
; Xu Z
; Shao J
Oncotarget
2017[Aug]; 8
(35
): 59638-59647
PMID28938667
show ga
The latest studies have shown that long non-coding RNAs (lncRNAs) may be
considered markers as their expression levels were abnormal in cancer and can be
used as a molecular biomarker for the potential assessment of cancer prognosis.
In this study, we aimed to assess the prognostic value of lncRNA as marker of
patients with hepatocellular carcinoma. We performed a detailed search of the
PubMed and Embase databases for articles on the prognostic value of various
lncRNAs in HCC. We then carefully extracted the relevant data from the articles,
and we used the meta-analysis method to analyze these results; heterogeneity and
publication bias were also evaluated. With 40 associative studies included, we
found that high expression of 27 types of lncRNA was associated with a poor
prognosis in HCC patients, and low expression of 18 types of lncRNAs was
associated with a worse prognosis. Patients with higher lncRNA expression had
significantly poor overall survival (OS; pooled HR, 1.25; 95% confidence interval
[CI], 1.03-1.52) as well as significantly poor recurrence-free survival (RFS;
pooled HR, 1.66; 95% CI, 1.26-2.17). Overexpression of lncRNAs may not
meaningfully predict disease-free survival (DFS; pooled HR, 1.04; 95% CI,
0.52-2.07; p = 0.91). Our meta-analysis demonstrated that lncRNAs may serve as
predictive biomarkers for cancer prognosis.