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2017 ; 8
(35
): 59518-59526
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Prognostic value of decreased long non-coding RNA TUSC7 expression in some solid
tumors: a systematic review and meta-analysis
#MMPMID28938655
Li N
; Yang M
; Shi K
; Li W
Oncotarget
2017[Aug]; 8
(35
): 59518-59526
PMID28938655
show ga
Accumulating evidences indicated that tumor suppressor candidate 7 (TUSC7) is a
putatively tumor suppressor gene in various tumors. We carried out current
systematic review and meta-analysis to explore the decreased expression of TUSC7
associate with prognostic and clinicopathological characteristic in cancer
patients. A literature collection search in the online electronic databases
PubMed, Embase, Web of Science, and CNKI was conducted to obtain eligible studies
(up to February 20, 2017). A total of nine studies comprise 757 patients were
identified and included in present meta-analysis based on the selection and
inclusion criteria. Overall, low expression of TUSC7 was associated with
significantly unfavorable overall survival (OS) (HR = 2.90, 95% CI: 2.12-3.98, P
< 0.001), disease free survival (DFS) (HR = 2.00, 95% CI: 1.49-2.68, P < 0.001)
and disease-specific survival (DSS) (HR = 2.57, 95% CI: 1.23-5.39, P = 0.012) in
tumors patients. Moreover, we also found that down-regulation of TUSC7 associated
with distant metastasis (OR = 2.85, 95% CI: 1.46-5.55, P = 0.002) and larger
tumor size (OR = 0.41, 95% CI: 0.23-0.72, P = 0.002). Our meta-analysis
demonstrated that cancers patients detected with low TUSC7 expression were more
prone to develop distant metastasis. TUSC7 might act as a potentially and
promising common prognostic markers in some solid tumors.
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