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2017 ; 8
(35
): 59282-59300
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
PATZ1 is a new prognostic marker of glioblastoma associated with the stem-like
phenotype and enriched in the proneural subtype
#MMPMID28938636
Guadagno E
; Vitiello M
; Francesca P
; Calì G
; Caponnetto F
; Cesselli D
; Camorani S
; Borrelli G
; Califano M
; Cappabianca P
; Arra C
; Crescenzi E
; Cerchia L
; De Caro MLDB
; Fedele M
Oncotarget
2017[Aug]; 8
(35
): 59282-59300
PMID28938636
show ga
Glioblastoma (GBM), the most malignant of the brain tumors, has been classified
on the basis of molecular signature into four subtypes: classical, mesenchymal,
proneural and neural, among which the mesenchymal and proneural subtypes have the
shortest and longest survival, respectively. Here we show that the transcription
factor PATZ1 gene is upregulated in gliomas compared to normal brain and, among
GBMs, is particularly enriched in the proneural subtype and co-localize with
stemness markers. Accordingly, in GBM-derived glioma-initiating stem cells (GSCs)
PATZ1 is overexpressed compared to differentiated tumor cells and its expression
significantly correlates with the characteristic stem cell capacity to grow as
neurospheres in vitro. Interestingly, survival analysis demonstrated that PATZ1
lower levels informed poor prognosis in GBM and, specifically, in the proneural
subgroup, suggesting it may serve a role as diagnostic and prognostic biomarker
for intra-subtype heterogeneity of proneural GBM. We also show that PATZ1
suppresses the expression of the mesenchyme-inducer CXCR4, and that PATZ1 and
CXCR4 are inversely correlated in GSC and proneural GBM. Overall these findings
support a central role of PATZ1 in regulating malignancy of GBM.
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