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2017 ; 8
(35
): 58709-58727
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Ocular toxicities associated with targeted anticancer agents: an analysis of
clinical data with management suggestions
#MMPMID28938590
Fu C
; Gombos DS
; Lee J
; George GC
; Hess K
; Whyte A
; Hong DS
Oncotarget
2017[Aug]; 8
(35
): 58709-58727
PMID28938590
show ga
Ocular toxicities are among the most common adverse events resulting from
targeted anticancer agents and are becoming increasingly relevant in the
management of patients on these agents. The purpose of this study is to provide a
framework for management of these challenging toxicities based on objective data
from FDA labels and from analysis of the literature. All oncologic drugs approved
by the FDA up to March 14, 2015, were screened for inclusion. A total of 16 drugs
(12 small-molecule drugs and 4 monoclonal antibodies) were analyzed for ocular
toxicity profiles based on evidence of ocular toxicity. Trials cited by FDA
labels were retrieved, and a combination search in Medline, Google Scholar, the
Cochrane database, and the NIH Clinical Trials Database was conducted. The
majority of ocular toxicities reported were low severity, and the most common
were conjunctivitis and "visual disturbances." However, severe events including
incidents of blindness, retinal vascular occlusion, and corneal ulceration
occurred. The frequency and severity at which ocular toxicities occur merits a
more multidisciplinary approach to managing patients with agents that are known
to cause ocular issues. We suggest a standardized methodology for referral and
surveillance of patients who are potentially at risk of severe ocular toxicity.
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