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10.18632/oncotarget.17024 http://scihub22266oqcxt.onion/10.18632/oncotarget.17024 C5601668!5601668!28938572     free     free     free       Oncotarget 2017 ; 8 (35): 58480-93 Nephropedia Template TP {{tp|p=28938572|t=2017. Osthole inhibits bone metastasis of breast cancer |pdf=|usr=}}{{28938572}} gab.com Text Osthole inhibits bone metastasis of breast cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28938572 #FOAvip Bone is one of the most common sites for breast cancer metastasis, which greatly contributes to patient morbidity and mortality. Osthole, a major extract from Cnidium monnieri (L.), exhibits many biological and pharmacological activities, however, its potential as a therapeutic agent in the treatment of breast cancer bone metastases remain poorly understood. In this study, we set out to investigate whether osthole could inhibit breast cancer metastasis to bone in mice and clarified the potential mechanism of this inhibition. In the murine model of breast cancer osseous metastasis, mice that received osthole developed significantly less bone metastases and displayed decreased tumor burden when compared with mice in the control group. Osthole inhibited breast cancer cell growth, migration, and invasion, and induced apoptosis of breast cancer cells. Additionally, it also regulated OPG/RANKL signals in the interactions between bone cells (osteoblasts and osteoclasts) and cancer cells. Besides, it also inhibited TGF-?/Smads signaling in breast cancer metastasis to bone in MDA-231BO cells. The results of this study suggest that osthole has real potential as a therapeutic candidate in the treatment of breast cancer patients with bone metastases. Twit Text FOAVip Osthole inhibits bone metastasis of breast cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28938572 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28938572 #FOAvip English Wikipedia <ref>{{Cite pmid|28938572}}</ref> Osthole inhibits bone metastasis of breast cancer #MMPMID28938572 Wu C; Sun Z; Guo B; Ye Y; Han X; Qin Y; Liu S Oncotarget 2017[Aug]; 8 (35): 58480-93 PMID28938572show ga Bone is one of the most common sites for breast cancer metastasis, which greatly contributes to patient morbidity and mortality. Osthole, a major extract from Cnidium monnieri (L.), exhibits many biological and pharmacological activities, however, its potential as a therapeutic agent in the treatment of breast cancer bone metastases remain poorly understood. In this study, we set out to investigate whether osthole could inhibit breast cancer metastasis to bone in mice and clarified the potential mechanism of this inhibition. In the murine model of breast cancer osseous metastasis, mice that received osthole developed significantly less bone metastases and displayed decreased tumor burden when compared with mice in the control group. Osthole inhibited breast cancer cell growth, migration, and invasion, and induced apoptosis of breast cancer cells. Additionally, it also regulated OPG/RANKL signals in the interactions between bone cells (osteoblasts and osteoclasts) and cancer cells. Besides, it also inhibited TGF-?/Smads signaling in breast cancer metastasis to bone in MDA-231BO cells. The results of this study suggest that osthole has real potential as a therapeutic candidate in the treatment of breast cancer patients with bone metastases. äOsthole inhibits bone metastasis of breast cancer (epmc).pdf DeepDyve Pubget Overpricing