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2017 ; 8
(35
): 58163-58171
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Overexpression of leptin receptor in human glioblastoma: Correlation with
vasculogenic mimicry and poor prognosis
#MMPMID28938545
Han G
; Li Y
; Cao Y
; Yue Z
; Zhang Y
; Wang L
; Liu J
Oncotarget
2017[Aug]; 8
(35
): 58163-58171
PMID28938545
show ga
Vasculogenic mimicry (VM) was an important tumor blood supply to complement the
endothelial cell-dependent angiogenesis, while leptin and receptor (ObR) involved
in angiogenesis in glioblastoma has been reported on previous study, but the
relationship between ObR expression and VM formation in human glioblastoma
tissues, as well as their prognostic significance still remains unclear. In our
study, we found that VM recognized by CD31-/PAS+ immunohistochemical staining in
glioblastoma tissues showed a positive correlation with leptin expression (r =
0.58, P < 0.01), as well as ObR expression in glioblastoma tissues (r = 0.61, P <
0.01). Association of glial to mesenchymal transition (GMT)-related molecular
with ObR expression and VM formation in glioblastoma tissues indicated that
ObR-positive glioblastoma cells with GMT phenotype might be more likely to
constitute VM, and co-expression of ObR and CD133 or Nestin to constitute the
channel impliated that ObR-positive glioblastoma cells displayed glioblastoma
stem cells (GSC) properties. Moreover, Kaplan-Meier statistical analysis showed
that patients with more VM or ObR expression displayed poorer prognosis for
overall survival times than patients with less expression (VM(high) vs. VM(low):
P = 0.033; ObR(high) vs. ObR(low): P = 0.009). And ObR+ glioblastoma cells with
GSC characteristic were mostly involved in VM formation, whereas a little part of
cells were also related to microvascular density (MVD), which suggested that ObR
was an important target for anticancer therapy, so further related studies were
needed to improve glioblastoma treatment.
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