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10.1038/s41467-017-00655-9 http://scihub22266oqcxt.onion/10.1038/s41467-017-00655-9 C5601476!5601476 !28916773     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28916773 &cmd=llinks): Failed to open stream: HTTP request failed! 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Functional organization of cytoplasmic inclusion bodies in cells infected by respiratory syncytial virus |pdf=|usr=}}{{28916773 }} gab.com Text Functional organization of cytoplasmic inclusion bodies in cells infected by respiratory syncytial virus JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28916773 #FOAvip Infection of cells by respiratory syncytial virus induces the formation of cytoplasmic inclusion bodies (IBs) where all the components of the viral RNA polymerase complex are concentrated. However, the exact organization and function of these IBs remain unclear. In this study, we use conventional and super-resolution imaging to dissect the internal structure of IBs. We observe that newly synthetized viral mRNA and the viral transcription anti-terminator M2-1 concentrate in IB sub-compartments, which we term "IB-associated granules" (IBAGs). In contrast, viral genomic RNA, the nucleoprotein, the L polymerase and its cofactor P are excluded from IBAGs. Live imaging reveals that IBAGs are highly dynamic structures. Our data show that IBs are the main site of viral RNA synthesis. They further suggest that shortly after synthesis in IBs, viral mRNAs and M2-1 transiently concentrate in IBAGs before reaching the cytosol and suggest a novel post-transcriptional function for M2-1.Respiratory syncytial virus (RSV) induces formation of inclusion bodies (IBs) sheltering viral RNA synthesis. Here, Rincheval et al. identify highly dynamic IB-associated granules (IBAGs) that accumulate newly synthetized viral mRNA and the viral M2-1 protein but exclude viral genomic RNA and RNA polymerase complexes. Twit Text FOAVip Functional organization of cytoplasmic inclusion bodies in cells infected by respiratory syncytial virus ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28916773 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28916773 #FOAvip English Wikipedia <ref>{{Cite pmid|28916773 }}</ref> Functional organization of cytoplasmic inclusion bodies in cells infected by respiratory syncytial virus #MMPMID28916773 Rincheval V ; Lelek M ; Gault E ; Bouillier C ; Sitterlin D ; Blouquit-Laye S ; Galloux M ; Zimmer C ; Eleouet JF ; Rameix-Welti MA Nat Commun 2017[Sep]; 8 (1 ): 563 PMID28916773 show ga Infection of cells by respiratory syncytial virus induces the formation of cytoplasmic inclusion bodies (IBs) where all the components of the viral RNA polymerase complex are concentrated. However, the exact organization and function of these IBs remain unclear. In this study, we use conventional and super-resolution imaging to dissect the internal structure of IBs. We observe that newly synthetized viral mRNA and the viral transcription anti-terminator M2-1 concentrate in IB sub-compartments, which we term "IB-associated granules" (IBAGs). In contrast, viral genomic RNA, the nucleoprotein, the L polymerase and its cofactor P are excluded from IBAGs. Live imaging reveals that IBAGs are highly dynamic structures. Our data show that IBs are the main site of viral RNA synthesis. They further suggest that shortly after synthesis in IBs, viral mRNAs and M2-1 transiently concentrate in IBAGs before reaching the cytosol and suggest a novel post-transcriptional function for M2-1.Respiratory syncytial virus (RSV) induces formation of inclusion bodies (IBs) sheltering viral RNA synthesis. Here, Rincheval et al. identify highly dynamic IB-associated granules (IBAGs) that accumulate newly synthetized viral mRNA and the viral M2-1 protein but exclude viral genomic RNA and RNA polymerase complexes. |Cell Line [MESH] |Cytoplasmic Granules/*metabolism [MESH] |DNA-Directed RNA Polymerases/metabolism [MESH] |Humans [MESH] |Inclusion Bodies/*metabolism [MESH] |Nucleoproteins/metabolism [MESH] |RNA, Messenger/*metabolism [MESH] |RNA, Viral/*metabolism [MESH] |Respiratory Syncytial Virus Infections/*metabolism [MESH] |Respiratory Syncytial Virus, Human/*metabolism [MESH]Functional organization of cytoplasmic inclusion bodies in cells infec(epmc).pdf DeepDyve Pubget Overpricing