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10.1021/acs.jmedchem.7b00058 http://scihub22266oqcxt.onion/10.1021/acs.jmedchem.7b00058 C5601361!5601361 !28482155     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28482155 &cmd=llinks): Failed to open stream: HTTP request failed! 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Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective |pdf=|usr=}}{{28482155 }} gab.com Text Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective JO: J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=28482155 #FOAvip The receptor for advanced glycation endproducts (RAGE) is an ubiquitous, transmembrane, immunoglobulin-like receptor that exists in multiple isoforms and binds to a diverse range of endogenous extracellular ligands and intracellular effectors. Ligand binding at the extracellular domain of RAGE initiates a complex intracellular signaling cascade, resulting in the production of reactive oxygen species (ROS), immunoinflammatory effects, cellular proliferation, or apoptosis with concomitant upregulation of RAGE itself. To date, research has mainly focused on the correlation between RAGE activity and pathological conditions, such as cancer, diabetes, cardiovascular diseases, and neurodegeneration. Because RAGE plays a role in many pathological disorders, it has become an attractive target for the development of inhibitors at the extracellular and intracellular domains. This review describes the role of endogenous RAGE ligands/effectors in normo- and pathophysiological processes, summarizes the current status of exogenous small-molecule inhibitors of RAGE and concludes by identifying key strategies for future therapeutic intervention. Twit Text FOAVip Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective ????J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=28482155 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28482155 #FOAvip English Wikipedia <ref>{{Cite pmid|28482155 }}</ref> Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective #MMPMID28482155 Bongarzone S ; Savickas V ; Luzi F ; Gee AD J Med Chem 2017[Sep]; 60 (17 ): 7213-7232 PMID28482155 show ga The receptor for advanced glycation endproducts (RAGE) is an ubiquitous, transmembrane, immunoglobulin-like receptor that exists in multiple isoforms and binds to a diverse range of endogenous extracellular ligands and intracellular effectors. Ligand binding at the extracellular domain of RAGE initiates a complex intracellular signaling cascade, resulting in the production of reactive oxygen species (ROS), immunoinflammatory effects, cellular proliferation, or apoptosis with concomitant upregulation of RAGE itself. To date, research has mainly focused on the correlation between RAGE activity and pathological conditions, such as cancer, diabetes, cardiovascular diseases, and neurodegeneration. Because RAGE plays a role in many pathological disorders, it has become an attractive target for the development of inhibitors at the extracellular and intracellular domains. This review describes the role of endogenous RAGE ligands/effectors in normo- and pathophysiological processes, summarizes the current status of exogenous small-molecule inhibitors of RAGE and concludes by identifying key strategies for future therapeutic intervention. |Animals [MESH] |Cardiovascular Diseases/drug therapy/metabolism [MESH] |Diabetes Mellitus/drug therapy/metabolism [MESH] |Drug Discovery/*methods [MESH] |Glycation End Products, Advanced/metabolism [MESH] |Humans [MESH] |Molecular Targeted Therapy/methods [MESH] |Neoplasms/drug therapy/metabolism [MESH] |Neurodegenerative Diseases/drug therapy/metabolism [MESH] |Protein Domains/drug effects [MESH] |Protein Isoforms/antagonists & inhibitors/chemistry/metabolism [MESH] |Reactive Oxygen Species/metabolism [MESH] |Receptor for Advanced Glycation End Products/*antagonists & inhibitors/chemistry/*metabolism [MESH]Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Me(epmc).pdf DeepDyve Pubget Overpricing