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2017 ; 8
(36
): 60358-60367
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Identification of hub genes involved in the development of hepatocellular
carcinoma by transcriptome sequencing
#MMPMID28947976
Zheng Y
; Long J
; Wu L
; Zhang H
; Li L
; Zheng Y
; Wang A
; Lin J
; Yang X
; Sang X
; Hu K
; Pan J
; Zhao H
Oncotarget
2017[Sep]; 8
(36
): 60358-60367
PMID28947976
show ga
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death. The
aim of this study was to identify underlying hub genes and dysregulated pathways
associated with the development of HCC using bioinformatics analysis.
Differentially expressed protein-coding genes were subjected to transcriptome
sequencing in 11 pairs of liver cancer tissue and matched adjacent non-cancerous
tissue. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG)
pathway enrichment analyses were performed, followed by protein-protein
interaction (PPI) network construction. Hub genes were identified via
centralities analysis and verified using published datasets. In total, 720
significantly differentially expressed protein-coding genes were identified in
the samples, including 335 upregulated genes and 385 downregulated genes. The
upregulated genes were significantly enriched in cell adhesion, biological
adhesion and cell-cell adhesion GO terms under biological process (BP).
Conversely, the downregulated genes were significantly enriched in embryonic
organ morphogenesis, embryonic organ development and embryonic morphogenesis. The
KEGG pathway analysis showed that the upregulated genes were enriched in
ECM-receptor interaction and focal adhesion pathways. Furthermore, the
downregulated genes were enriched in the ErbB, VEGF and MAPK signaling pathways.
The PPI network and centralities analysis suggested that ITGA2 and 12 alternate
genes were significant hub genes. These findings improve current understanding of
the molecular mechanisms underlying HCC development and may be helpful in
identifying candidate molecular biomarkers for use in diagnosing, treating and
monitoring the prognosis of HCC.
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