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10.3389/fgene.2017.00118 http://scihub22266oqcxt.onion/10.3389/fgene.2017.00118 C5600918!5600918!28955379     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Genet 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28955379|t=2017. RIG-I-Like Receptor Signaling in Singleton-Merten Syndrome |pdf=|usr=}}{{28955379}} gab.com Text RIG-I-Like Receptor Signaling in Singleton-Merten Syndrome JO: Front Genet http://www.kidney.de/pget.php?&tw=1&pmid=28955379 #FOAvip Singleton-Merten syndrome (SMS) is an autosomal dominant, multi-system innate immune disorder characterized by early and severe aortic and valvular calcification, dental and skeletal abnormalities, psoriasis, glaucoma, and other varying clinical findings. Recently we identified a specific gain-of-function mutation in IFIH1, interferon induced with helicase C domain 1, segregated with this disease. SMS disease without hallmark dental anomalies, termed atypical SMS, has recently been reported caused by variants in DDX58, DEXD/H-box helicase 58. IFIH1 and DDX58 encode retinoic acid-inducible gene I (RIG-I)-like receptors family members melanoma differentiation-associated gene 5 and RIG-I, respectively. These cytosolic pattern recognition receptors function in viral RNA detection initiating an innate immune response through independent pathways that promote type I and type III interferon expression and proinflammatory cytokines. In this review, we focus on SMS as an innate immune disorder summarizing clinical features, molecular aspects of the pathogenetic pathway and discussing underlying mechanisms of the disease. Twit Text FOAVip RIG-I-Like Receptor Signaling in Singleton-Merten Syndrome ????Front Genet http://www.kidney.de/pget.php?&tw=1&pmid=28955379 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28955379 #FOAvip English Wikipedia <ref>{{Cite pmid|28955379}}</ref> RIG-I-Like Receptor Signaling in Singleton-Merten Syndrome #MMPMID28955379 Lu C; MacDougall M Front Genet 2017[]; 8 (ä): ä PMID28955379show ga Singleton-Merten syndrome (SMS) is an autosomal dominant, multi-system innate immune disorder characterized by early and severe aortic and valvular calcification, dental and skeletal abnormalities, psoriasis, glaucoma, and other varying clinical findings. Recently we identified a specific gain-of-function mutation in IFIH1, interferon induced with helicase C domain 1, segregated with this disease. SMS disease without hallmark dental anomalies, termed atypical SMS, has recently been reported caused by variants in DDX58, DEXD/H-box helicase 58. IFIH1 and DDX58 encode retinoic acid-inducible gene I (RIG-I)-like receptors family members melanoma differentiation-associated gene 5 and RIG-I, respectively. These cytosolic pattern recognition receptors function in viral RNA detection initiating an innate immune response through independent pathways that promote type I and type III interferon expression and proinflammatory cytokines. In this review, we focus on SMS as an innate immune disorder summarizing clinical features, molecular aspects of the pathogenetic pathway and discussing underlying mechanisms of the disease. äRIG-I-Like Receptor Signaling in Singleton-Merten Syndrome (epmc).pdf DeepDyve Pubget Overpricing