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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Semin+Immunopathol
2015 ; 37
(3
): 211-20
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From the draining lymph node to the liver: the induction and effector mechanisms
of malaria-specific CD8+ T cells
#MMPMID25917387
Radtke AJ
; Tse SW
; Zavala F
Semin Immunopathol
2015[May]; 37
(3
): 211-20
PMID25917387
show ga
Parasitic protozoa cause considerable disease in humans and, due to their
intracellular life cycle, induce robust CD8(+) T cell responses. A greater
understanding of the factors that promote and maintain CD8(+) T cell-mediated
immunity against these pathogens is likely needed for the development of
effective vaccines. Immunization with radiation-attenuated sporozoites, the
infectious stage of the malaria parasite transmitted by mosquitoes, is an
excellent model to study these questions as CD8(+) T cells specific for a single
epitope can completely eliminate parasite infection in the liver. Furthermore,
live, radiation-attenuated parasites represent the "gold standard" for malaria
vaccination. Here, we will highlight recent studies aimed at understanding the
factors required for the induction, recruitment, and maintenance of effector and
memory CD8(+) T cells against malaria liver stages.
|Adaptive Immunity
[MESH]
|Antigen Presentation/immunology
[MESH]
|Antigens, Protozoan
[MESH]
|CD8-Positive T-Lymphocytes/*immunology
[MESH]
|Cell Movement
[MESH]
|Cytotoxicity, Immunologic
[MESH]
|Host-Parasite Interactions/*immunology
[MESH]
|Humans
[MESH]
|Immunity, Innate
[MESH]
|Immunologic Memory
[MESH]
|Life Cycle Stages/immunology
[MESH]
|Liver/*immunology
[MESH]
|Lymph Nodes/*immunology
[MESH]
|Malaria Vaccines/immunology
[MESH]
|Malaria/*immunology/parasitology/prevention & control
[MESH]