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10.1038/s41525-016-0002-3 http://scihub22266oqcxt.onion/10.1038/s41525-016-0002-3 C5600530!5600530!28919981     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       NPJ+Genom+Med 2017 ; 2 (ä): ä Nephropedia Template TP {{tp|p=28919981|t=2017. Regulation of cancer epigenomes with a histone-binding synthetic transcription factor |pdf=|usr=}}{{28919981}} gab.com Text Regulation of cancer epigenomes with a histone-binding synthetic transcription factor JO: NPJ Genom Med http://www.kidney.de/pget.php?&tw=1&pmid=28919981 #FOAvip Chromatin proteins have expanded the mammalian synthetic biology toolbox by enabling control of active and silenced states at endogenous genes. Others have reported synthetic proteins that bind DNA and regulate genes by altering chromatin marks, such as histone modifications. Previously, we reported the first synthetic transcriptional activator, the ?Polycomb-based transcription factor? (PcTF) that reads histone modifications through a protein?protein interaction between the polycomb chromodomain motif and trimethylated lysine 27 of histone H3 (H3K27me3). Here, we describe the genome-wide behavior of the polycomb-based transcription factor fusion protein. Transcriptome and chromatin profiling revealed several polycomb-based transcription factor-sensitive promoter regions marked by distal H3K27me3 and proximal fusion protein binding. These results illuminate a mechanism in which polycomb-based transcription factor interactions bridge epigenomic marks with the transcription initiation complex at target genes. In three cancer-derived human cell lines tested here, some target genes encode developmental regulators and tumor suppressors. Thus, the polycomb-based transcription factor represents a powerful new fusion protein-based method for cancer research and treatment where silencing marks are translated into direct gene activation. Twit Text FOAVip Regulation of cancer epigenomes with a histone-binding synthetic transcription factor ????NPJ Genom Med http://www.kidney.de/pget.php?&tw=1&pmid=28919981 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28919981 #FOAvip English Wikipedia <ref>{{Cite pmid|28919981}}</ref> Regulation of cancer epigenomes with a histone-binding synthetic transcription factor #MMPMID28919981 Nyer DB; Daer RM; Vargas D; Hom C; Haynes KA NPJ Genom Med 2017[]; 2 (ä): ä PMID28919981show ga Chromatin proteins have expanded the mammalian synthetic biology toolbox by enabling control of active and silenced states at endogenous genes. Others have reported synthetic proteins that bind DNA and regulate genes by altering chromatin marks, such as histone modifications. Previously, we reported the first synthetic transcriptional activator, the ?Polycomb-based transcription factor? (PcTF) that reads histone modifications through a protein?protein interaction between the polycomb chromodomain motif and trimethylated lysine 27 of histone H3 (H3K27me3). Here, we describe the genome-wide behavior of the polycomb-based transcription factor fusion protein. Transcriptome and chromatin profiling revealed several polycomb-based transcription factor-sensitive promoter regions marked by distal H3K27me3 and proximal fusion protein binding. These results illuminate a mechanism in which polycomb-based transcription factor interactions bridge epigenomic marks with the transcription initiation complex at target genes. In three cancer-derived human cell lines tested here, some target genes encode developmental regulators and tumor suppressors. Thus, the polycomb-based transcription factor represents a powerful new fusion protein-based method for cancer research and treatment where silencing marks are translated into direct gene activation. äRegulation of cancer epigenomes with a histone-binding synthetic trans(epmc).pdf DeepDyve Pubget Overpricing