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10.1016/j.bbrep.2015.11.022 http://scihub22266oqcxt.onion/10.1016/j.bbrep.2015.11.022 C5600362!5600362 !28955817     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28955817 &cmd=llinks): Failed to open stream: HTTP request failed! 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Macrophage depletion by clodronate liposome attenuates muscle injury and inflammation following exhaustive exercise |pdf=|usr=}}{{28955817 }} gab.com Text Macrophage depletion by clodronate liposome attenuates muscle injury and inflammation following exhaustive exercise JO: Biochem Biophys Rep http://www.kidney.de/pget.php?&tw=1&pmid=28955817 #FOAvip Exhaustive exercise promotes muscle injury, including myofiber lesions; however, its exact mechanism has not yet been elucidated. In this study, we tested the hypothesis that macrophage depletion by pretreatment with clodronate liposomes alters muscle injury and inflammation following exhaustive exercise. Male C57BL/6J mice were divided into four groups: rest plus control liposome (n=8), rest plus clodronate liposome (n=8), exhaustive exercise plus control liposome (n=8), and exhaustive exercise plus clodronate liposome (n=8). Mice were treated with clodronate liposome or control liposome for 48 h before undergoing exhaustive exercise on a treadmill. Twenty-four hours after exhaustive exercise, the gastrocnemius muscles were removed for histological and PCR analyses. Exhaustive exercise increased the number of macrophages in the muscle; however, clodronate liposome treatment reduced this infiltration. Although exhaustive exercise resulted in an increase in injured myofibers, clodronate liposome treatment following exhaustive exercise reduced the injured myofibers. Clodronate liposome treatment also decreased the mRNA expression levels of inflammatory cytokines (TNF-?, IL-1?, and IL-6) in the skeletal muscle after exhaustive exercise. These results suggest that macrophages play a critical role in increasing muscle injury by regulating inflammation. Twit Text FOAVip Macrophage depletion by clodronate liposome attenuates muscle injury and inflammation following exhaustive exercise ????Biochem Biophys Rep http://www.kidney.de/pget.php?&tw=1&pmid=28955817 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28955817 #FOAvip English Wikipedia <ref>{{Cite pmid|28955817 }}</ref> Macrophage depletion by clodronate liposome attenuates muscle injury and inflammation following exhaustive exercise #MMPMID28955817 Kawanishi N ; Mizokami T ; Niihara H ; Yada K ; Suzuki K Biochem Biophys Rep 2016[Mar]; 5 (ä): 146-151 PMID28955817 show ga Exhaustive exercise promotes muscle injury, including myofiber lesions; however, its exact mechanism has not yet been elucidated. In this study, we tested the hypothesis that macrophage depletion by pretreatment with clodronate liposomes alters muscle injury and inflammation following exhaustive exercise. Male C57BL/6J mice were divided into four groups: rest plus control liposome (n=8), rest plus clodronate liposome (n=8), exhaustive exercise plus control liposome (n=8), and exhaustive exercise plus clodronate liposome (n=8). Mice were treated with clodronate liposome or control liposome for 48 h before undergoing exhaustive exercise on a treadmill. Twenty-four hours after exhaustive exercise, the gastrocnemius muscles were removed for histological and PCR analyses. Exhaustive exercise increased the number of macrophages in the muscle; however, clodronate liposome treatment reduced this infiltration. Although exhaustive exercise resulted in an increase in injured myofibers, clodronate liposome treatment following exhaustive exercise reduced the injured myofibers. Clodronate liposome treatment also decreased the mRNA expression levels of inflammatory cytokines (TNF-?, IL-1?, and IL-6) in the skeletal muscle after exhaustive exercise. These results suggest that macrophages play a critical role in increasing muscle injury by regulating inflammation. äMacrophage depletion by clodronate liposome attenuates muscle injury a(epmc).pdf DeepDyve Pubget Overpricing