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10.1016/j.bbrep.2015.11.021

http://scihub22266oqcxt.onion/10.1016/j.bbrep.2015.11.021
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suck abstract from ncbi


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pmid28955801      Biochem+Biophys+Rep 2016 ; 5 (ä): 1-7
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  • Up-regulation of Syndecan-4 contributes to TGF-?1-induced epithelial to mesenchymal transition in lung adenocarcinoma A549 cells #MMPMID28955801
  • Toba-Ichihashi Y; Yamaoka T; Ohmori T; Ohba M
  • Biochem Biophys Rep 2016[Mar]; 5 (ä): 1-7 PMID28955801show ga
  • Syndecan-4 (SDC4) is a cell-surface proteoglycan associated with cell adhesion, motility, and intracellular signaling. Here, we present that SDC4 functions as a positive regulator of the transforming growth factor (TGF)-?1-induced epithelial to mesenchymal transition (EMT) via Snail in lung adenocarcinoma, A549 cells. TGF-?1 up-regulated the expression of SDC4, accompanied by the induction of EMT. Wound-healing and transwell chemotaxis assay revealed that SDC4 promoted cell migration and invasion. SDC4 knockdown recovered the E-cadherin and decreased vimentin and Snail expression in EMT-induced A549 cells. However, depletion of SDC4 resulted in little change of the Slug protein expression and mesenchymal cell morphology induced by TGF-?1. The double knockdown of SDC-4 and Slug was required for reversal of epithelial morphology; it did not occur from the SDC4 single knockdown. These findings suggest that Snail is a transcriptional factor downstream of SDC4, and SDC4 regulates TGF-?1-induced EMT by cooperating with Slug. Our data provide a novel insight into cellular mechanisms, whereby the cell-surface proteoglycan modulated TGF-?1-induced EMT in lung adenocarcinoma, A549 cells.
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