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10.7150/ijms.20336 http://scihub22266oqcxt.onion/10.7150/ijms.20336 C5599922!5599922 !28924370     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28924370 &cmd=llinks): Failed to open stream: HTTP request failed! 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Kaempferol Inhibits the Invasion and Migration of Renal Cancer Cells through the Downregulation of AKT and FAK Pathways |pdf=|usr=}}{{28924370 }} gab.com Text Kaempferol Inhibits the Invasion and Migration of Renal Cancer Cells through the Downregulation of AKT and FAK Pathways JO: Int J Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=28924370 #FOAvip Kaempferol, which is isolated from several natural plants, is a polyphenol belonging to the subgroup of flavonoids. Kaempferol exhibits various pharmacological activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer activities. In this study, kaempferol can significantly inhibit the invasion and migration of 786-O renal cell carcinoma (RCC) without cytotoxicity. We examined the potential mechanisms underlying its anti-invasive activities on 786-O RCC cells. Western blot was performed, and the results showed that kaempferol attenuates the manifestation of metalloproteinase-2 (MMP-2) protein and activity. The inhibitive effect of kaempferol on MMP-2 may be attributed to the downregulation of phosphorylation of Akt and focal adhesion kinase (FAK). By examining the SCID mice model, we found that kaempferol can safely inhibit the metastasis of the 786-O RCC cells into the lungs by about 87.4% as compared to vehicle treated control animals. In addition, the lung tumor masses of mice pretreated with 2-10 mg/kg kaempferol were reduced about twofold to fourfold. These data suggested that kaempferol can play a promising role in tumor prevention and cancer metastasis inhibition. Twit Text FOAVip Kaempferol Inhibits the Invasion and Migration of Renal Cancer Cells through the Downregulation of AKT and FAK Pathways ????Int J Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=28924370 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28924370 #FOAvip English Wikipedia <ref>{{Cite pmid|28924370 }}</ref> Kaempferol Inhibits the Invasion and Migration of Renal Cancer Cells through the Downregulation of AKT and FAK Pathways #MMPMID28924370 Hung TW ; Chen PN ; Wu HC ; Wu SW ; Tsai PY ; Hsieh YS ; Chang HR Int J Med Sci 2017[]; 14 (10 ): 984-993 PMID28924370 show ga Kaempferol, which is isolated from several natural plants, is a polyphenol belonging to the subgroup of flavonoids. Kaempferol exhibits various pharmacological activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer activities. In this study, kaempferol can significantly inhibit the invasion and migration of 786-O renal cell carcinoma (RCC) without cytotoxicity. We examined the potential mechanisms underlying its anti-invasive activities on 786-O RCC cells. Western blot was performed, and the results showed that kaempferol attenuates the manifestation of metalloproteinase-2 (MMP-2) protein and activity. The inhibitive effect of kaempferol on MMP-2 may be attributed to the downregulation of phosphorylation of Akt and focal adhesion kinase (FAK). By examining the SCID mice model, we found that kaempferol can safely inhibit the metastasis of the 786-O RCC cells into the lungs by about 87.4% as compared to vehicle treated control animals. In addition, the lung tumor masses of mice pretreated with 2-10 mg/kg kaempferol were reduced about twofold to fourfold. These data suggested that kaempferol can play a promising role in tumor prevention and cancer metastasis inhibition. |Animals [MESH] |Antineoplastic Agents/*pharmacology/therapeutic use [MESH] |Carcinoma, Renal Cell/*drug therapy/secondary [MESH] |Cell Line, Tumor [MESH] |Cell Movement/*drug effects [MESH] |Down-Regulation [MESH] |Female [MESH] |Focal Adhesion Kinase 1/metabolism [MESH] |Humans [MESH] |Kaempferols/*pharmacology/therapeutic use [MESH] |Kidney Neoplasms/*drug therapy/pathology [MESH] |Lung Neoplasms/*drug therapy/secondary [MESH] |Matrix Metalloproteinase 2/metabolism [MESH] |Mice [MESH] |Mice, SCID [MESH] |Neoplasm Invasiveness [MESH] |Phosphorylation [MESH] |Proto-Oncogene Proteins c-akt/metabolism [MESH] |Signal Transduction/*drug effects [MESH]Kaempferol Inhibits the Invasion and Migration of Renal Cancer Cells t(epmc).pdf DeepDyve Pubget Overpricing