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10.7150/ijbs.19191 http://scihub22266oqcxt.onion/10.7150/ijbs.19191 C5599903!5599903 !28924379     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28924379 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Biol+Sci 2017 ; 13 (8 ): 976-984 Nephropedia Template TP {{tp|p=28924379 |t=2017. The Overexpression of CARM1 Promotes Human Osteosarcoma Cell Proliferation through the pGSK3?/?-Catenin/cyclinD1 Signaling Pathway |pdf=|usr=}}{{28924379 }} gab.com Text The Overexpression of CARM1 Promotes Human Osteosarcoma Cell Proliferation through the pGSK3 / -Catenin/cyclinD1 Signaling Pathway JO: Int J Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28924379 #FOAvip Osteosarcoma (OS) is a kind of malignant bone tumor that occurs frequently in the region surrounding the knee joint and poses a threat to the health of teenagers. Since the application of chemotherapy to treat OS, 5-year survival rate in patients has improved from 10% to 70%, but patient survival has not changed over the past four decades. Coactivator-associated arginine methyltransferase 1 (CARM1) is a member of the PRMT protein family; it acts as an oncogene in many cancers, but its function in OS is still unknown. In this study, we found that CARM1 is overexpressed in OS and its expression is correlated with the Enneking stage. CCK-8 and colony forming assays showed that proliferation in OS cell lines was downregulated when siRNA was used to knockdown CARM1 expression. The cell cycle was inhibited in S phase after si-CARM1 transfection in OS cell lines. An antibody array indicated that Erk1/2 (Thr202/Tyr204), PARS40 (Thr246), and GSK3? (Ser9) expression are affected by CARM1, and western blotting verified that CARM1 promotes OS cell proliferation via pGSK3?/?-catenin/cyclinD1 signaling. Accordingly, CARM1 is a crucial gene in OS and is a potential new treatment target. Twit Text FOAVip The Overexpression of CARM1 Promotes Human Osteosarcoma Cell Proliferation through the pGSK3 / -Catenin/cyclinD1 Signaling Pathway ????Int J Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28924379 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28924379 #FOAvip English Wikipedia <ref>{{Cite pmid|28924379 }}</ref> The Overexpression of CARM1 Promotes Human Osteosarcoma Cell Proliferation through the pGSK3?/?-Catenin/cyclinD1 Signaling Pathway #MMPMID28924379 Li S ; Cheng D ; Zhu B ; Yang Q Int J Biol Sci 2017[]; 13 (8 ): 976-984 PMID28924379 show ga Osteosarcoma (OS) is a kind of malignant bone tumor that occurs frequently in the region surrounding the knee joint and poses a threat to the health of teenagers. Since the application of chemotherapy to treat OS, 5-year survival rate in patients has improved from 10% to 70%, but patient survival has not changed over the past four decades. Coactivator-associated arginine methyltransferase 1 (CARM1) is a member of the PRMT protein family; it acts as an oncogene in many cancers, but its function in OS is still unknown. In this study, we found that CARM1 is overexpressed in OS and its expression is correlated with the Enneking stage. CCK-8 and colony forming assays showed that proliferation in OS cell lines was downregulated when siRNA was used to knockdown CARM1 expression. The cell cycle was inhibited in S phase after si-CARM1 transfection in OS cell lines. An antibody array indicated that Erk1/2 (Thr202/Tyr204), PARS40 (Thr246), and GSK3? (Ser9) expression are affected by CARM1, and western blotting verified that CARM1 promotes OS cell proliferation via pGSK3?/?-catenin/cyclinD1 signaling. Accordingly, CARM1 is a crucial gene in OS and is a potential new treatment target. |Cell Cycle/genetics/physiology [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/genetics/*physiology [MESH] |Cyclin D1/*metabolism [MESH] |Gene Expression Regulation, Neoplastic/genetics/physiology [MESH] |Glycogen Synthase Kinase 3 beta/*metabolism [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |In Vitro Techniques [MESH] |Osteosarcoma/genetics/*metabolism [MESH] |Protein-Arginine N-Methyltransferases/genetics/*metabolism [MESH]The Overexpression of CARM1 Promotes Human Osteosarcoma Cell Prolifera(epmc).pdf DeepDyve Pubget Overpricing