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10.1038/s41467-017-00700-7 http://scihub22266oqcxt.onion/10.1038/s41467-017-00700-7 C5599653!5599653 !28912547     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28912547 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (1 ): 532 Nephropedia Template TP {{tp|p=28912547 |t=2017. A systematic exploration of the interactions between bacterial effector proteins and host cell membranes |pdf=|usr=}}{{28912547 }} gab.com Text A systematic exploration of the interactions between bacterial effector proteins and host cell membranes JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28912547 #FOAvip Membrane-bound organelles serve as platforms for the assembly of multi-protein complexes that function as hubs of signal transduction in eukaryotic cells. Microbial pathogens have evolved virulence factors that reprogram these host signaling responses, but the underlying molecular mechanisms are poorly understood. Here we test the ability of ~200 type III and type IV effector proteins from six Gram-negative bacterial species to interact with the eukaryotic plasma membrane and intracellular organelles. We show that over 30% of the effectors localize to yeast and mammalian cell membranes, including a subset of previously uncharacterized Legionella effectors that appear to be able to regulate yeast vacuolar fusion. A combined genetic, cellular, and biochemical approach supports that some of the tested bacterial effectors can bind to membrane phospholipids and may regulate membrane trafficking. Finally, we show that the type III effector IpgB1 from Shigella flexneri may bind to acidic phospholipids and regulate actin filament dynamics.Microbial pathogens secrete effector proteins into host cells to affect cellular functions. Here, the authors use a yeast-based screen to study around 200 effectors from six bacterial species, showing that over 30% of them interact with the eukaryotic plasma membrane or intracellular organelles. Twit Text FOAVip A systematic exploration of the interactions between bacterial effector proteins and host cell membranes ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28912547 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28912547 #FOAvip English Wikipedia <ref>{{Cite pmid|28912547 }}</ref> A systematic exploration of the interactions between bacterial effector proteins and host cell membranes #MMPMID28912547 Weigele BA ; Orchard RC ; Jimenez A ; Cox GW ; Alto NM Nat Commun 2017[Sep]; 8 (1 ): 532 PMID28912547 show ga Membrane-bound organelles serve as platforms for the assembly of multi-protein complexes that function as hubs of signal transduction in eukaryotic cells. Microbial pathogens have evolved virulence factors that reprogram these host signaling responses, but the underlying molecular mechanisms are poorly understood. Here we test the ability of ~200 type III and type IV effector proteins from six Gram-negative bacterial species to interact with the eukaryotic plasma membrane and intracellular organelles. We show that over 30% of the effectors localize to yeast and mammalian cell membranes, including a subset of previously uncharacterized Legionella effectors that appear to be able to regulate yeast vacuolar fusion. A combined genetic, cellular, and biochemical approach supports that some of the tested bacterial effectors can bind to membrane phospholipids and may regulate membrane trafficking. Finally, we show that the type III effector IpgB1 from Shigella flexneri may bind to acidic phospholipids and regulate actin filament dynamics.Microbial pathogens secrete effector proteins into host cells to affect cellular functions. Here, the authors use a yeast-based screen to study around 200 effectors from six bacterial species, showing that over 30% of them interact with the eukaryotic plasma membrane or intracellular organelles. |Bacterial Proteins/genetics/*metabolism [MESH] |Cell Membrane/*metabolism [MESH] |HEK293 Cells [MESH] |HeLa Cells [MESH] |Host-Pathogen Interactions/*physiology [MESH] |Humans [MESH] |Legionella pneumophila/metabolism/pathogenicity [MESH] |Membrane Lipids/metabolism [MESH] |Microscopy, Fluorescence [MESH] |Phospholipids/metabolism [MESH] |Saccharomyces cerevisiae/genetics/metabolism [MESH] |Shigella flexneri/metabolism/pathogenicity [MESH]A systematic exploration of the interactions between bacterial effecto(epmc).pdf DeepDyve Pubget Overpricing