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10.1038/s41467-017-00583-8 http://scihub22266oqcxt.onion/10.1038/s41467-017-00583-8 C5599609!5599609 !28912446     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28912446 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (1 ): 533 Nephropedia Template TP {{tp|p=28912446 |t=2017. An injectable hydrogel enhances tissue repair after spinal cord injury by promoting extracellular matrix remodeling |pdf=|usr=}}{{28912446 }} gab.com Text An injectable hydrogel enhances tissue repair after spinal cord injury by promoting extracellular matrix remodeling JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28912446 #FOAvip The cystic cavity that develops following injuries to brain or spinal cord is a major obstacle for tissue repair in central nervous system (CNS). Here we report that injection of imidazole-poly(organophosphazenes) (I-5), a hydrogel with thermosensitive sol-gel transition behavior, almost completely eliminates cystic cavities in a clinically relevant rat spinal cord injury model. Cystic cavities are bridged by fibronectin-rich extracellular matrix. The fibrotic extracellular matrix remodeling is mediated by matrix metalloproteinase-9 expressed in macrophages within the fibrotic extracellular matrix. A poly(organophosphazenes) hydrogel lacking the imidazole moiety, which physically interacts with macrophages via histamine receptors, exhibits substantially diminished bridging effects. I-5 injection improves coordinated locomotion, and this functional recovery is accompanied by preservation of myelinated white matter and motor neurons and an increase in axonal reinnervation of the lumbar motor neurons. Our study demonstrates that dynamic interactions between inflammatory cells and injectable biomaterials can induce beneficial extracellular matrix remodeling to stimulate tissue repair following CNS injuries.The cystic cavity that develops following injuries to brain or spinal cord is a major obstacle. Here the authors show an injection of imidazole poly(organophosphazenes), a hydrogel with thermosensitive sol-gel transition behavior, almost completely eliminates cystic cavities in a clinically relevant rat spinal cord injury model. Twit Text FOAVip An injectable hydrogel enhances tissue repair after spinal cord injury by promoting extracellular matrix remodeling ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28912446 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28912446 #FOAvip English Wikipedia <ref>{{Cite pmid|28912446 }}</ref> An injectable hydrogel enhances tissue repair after spinal cord injury by promoting extracellular matrix remodeling #MMPMID28912446 Hong LTA ; Kim YM ; Park HH ; Hwang DH ; Cui Y ; Lee EM ; Yahn S ; Lee JK ; Song SC ; Kim BG Nat Commun 2017[Sep]; 8 (1 ): 533 PMID28912446 show ga The cystic cavity that develops following injuries to brain or spinal cord is a major obstacle for tissue repair in central nervous system (CNS). Here we report that injection of imidazole-poly(organophosphazenes) (I-5), a hydrogel with thermosensitive sol-gel transition behavior, almost completely eliminates cystic cavities in a clinically relevant rat spinal cord injury model. Cystic cavities are bridged by fibronectin-rich extracellular matrix. The fibrotic extracellular matrix remodeling is mediated by matrix metalloproteinase-9 expressed in macrophages within the fibrotic extracellular matrix. A poly(organophosphazenes) hydrogel lacking the imidazole moiety, which physically interacts with macrophages via histamine receptors, exhibits substantially diminished bridging effects. I-5 injection improves coordinated locomotion, and this functional recovery is accompanied by preservation of myelinated white matter and motor neurons and an increase in axonal reinnervation of the lumbar motor neurons. Our study demonstrates that dynamic interactions between inflammatory cells and injectable biomaterials can induce beneficial extracellular matrix remodeling to stimulate tissue repair following CNS injuries.The cystic cavity that develops following injuries to brain or spinal cord is a major obstacle. Here the authors show an injection of imidazole poly(organophosphazenes), a hydrogel with thermosensitive sol-gel transition behavior, almost completely eliminates cystic cavities in a clinically relevant rat spinal cord injury model. |Animals [MESH] |Extracellular Matrix/*physiology [MESH] |Female [MESH] |Fibronectins/metabolism [MESH] |Hydrogels/*administration & dosage/chemistry [MESH] |Imidazoles/chemical synthesis/chemistry [MESH] |Macrophages/physiology [MESH] |Matrix Metalloproteinase 9/genetics [MESH] |Mice [MESH] |NIH 3T3 Cells [MESH] |Polymers/chemical synthesis/chemistry [MESH] |Rats, Sprague-Dawley [MESH] |Regeneration/*physiology [MESH] |Spinal Cord Injuries/pathology/*therapy [MESH]An injectable hydrogel enhances tissue repair after spinal cord injury(epmc).pdf DeepDyve Pubget Overpricing