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10.1038/s41598-017-11885-8 http://scihub22266oqcxt.onion/10.1038/s41598-017-11885-8 C5599596!5599596!28912531     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28912531|t=2017. TGF-?1-induced miR-503 controls cell growth and apoptosis by targeting PDCD4 in glioblastoma cells |pdf=|usr=}}{{28912531}} gab.com Text TGF- 1-induced miR-503 controls cell growth and apoptosis by targeting PDCD4 in glioblastoma cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28912531 #FOAvip Aberrant expression of microRNAs hae been shown to be closely associated with glioblastoma cell proliferation, apoptosis and drug resistance. However, mechanisms underlying the role of mcroRNAs in glioblastoma cell growth and apoptosis are not fully understood. In this study, we report that miR-503 is overexpressed in glioblastoma tissue compared with normal human brain tissue. Mechanistically, miR-503 can be induced by TGF-?1 at the transcriptional level by binding the smad2/3 binding elements in the promoter. Ectopic overexpression of miR-503 promotes cell growth and inhibits apoptosis by targeting PDCD4. In contrast, inhibition of miR-503 reduces cell growth. Furthermore, miR-503 inhibitor augments the growth inhibitory effect of temozolomide in glioblastoma cells. These results establish miR-503 as a promising molecular target for glioblastoma therapy. Twit Text FOAVip TGF- 1-induced miR-503 controls cell growth and apoptosis by targeting PDCD4 in glioblastoma cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28912531 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28912531 #FOAvip English Wikipedia <ref>{{Cite pmid|28912531}}</ref> TGF-?1-induced miR-503 controls cell growth and apoptosis by targeting PDCD4 in glioblastoma cells #MMPMID28912531 Guo P; Yu Y; Li H; Zhang D; Gong A; Li S; Liu W; Cheng L; Qiu Y; Yao W; Li L; Feng Y Sci Rep 2017[]; 7 (ä): ä PMID28912531show ga Aberrant expression of microRNAs hae been shown to be closely associated with glioblastoma cell proliferation, apoptosis and drug resistance. However, mechanisms underlying the role of mcroRNAs in glioblastoma cell growth and apoptosis are not fully understood. In this study, we report that miR-503 is overexpressed in glioblastoma tissue compared with normal human brain tissue. Mechanistically, miR-503 can be induced by TGF-?1 at the transcriptional level by binding the smad2/3 binding elements in the promoter. Ectopic overexpression of miR-503 promotes cell growth and inhibits apoptosis by targeting PDCD4. In contrast, inhibition of miR-503 reduces cell growth. Furthermore, miR-503 inhibitor augments the growth inhibitory effect of temozolomide in glioblastoma cells. These results establish miR-503 as a promising molecular target for glioblastoma therapy. äTGF-?1-induced miR-503 controls cell growth and apoptosis by targeting(epmc).pdf DeepDyve Pubget Overpricing