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10.1038/s41598-017-08617-3 http://scihub22266oqcxt.onion/10.1038/s41598-017-08617-3 C5599553!5599553 !28912528     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28912528 &cmd=llinks): Failed to open stream: HTTP request failed! 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Extracellular vesicles derived from T regulatory cells suppress T cell proliferation and prolong allograft survival |pdf=|usr=}}{{28912528 }} gab.com Text Extracellular vesicles derived from T regulatory cells suppress T cell proliferation and prolong allograft survival JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28912528 #FOAvip We have previously shown that rat allogeneic DC, made immature by adenoviral gene transfer of the dominant negative form of IKK2, gave rise in-vitro to a unique population of CD4(+)CD25(-) regulatory T cells (dnIKK2-Treg). These cells inhibited Tcell response in-vitro, without needing cell-to-cell contact, and induced kidney allograft survival prolongation in-vivo. Deep insight into the mechanisms behind dnIKK2-Treg-induced suppression of Tcell proliferation remained elusive. Here we document that dnIKK2-Treg release extracellular vesicles (EV) riched in exosomes, fully accounting for the cell-contact independent immunosuppressive activity of parent cells. DnIKK2-Treg-EV contain a unique molecular cargo of specific miRNAs and iNOS, which, once delivered into target cells, blocked cell cycle progression and induced apoptosis. DnIKK2-Treg-EV-exposed T cells were in turn converted into regulatory cells. Notably, when administered in-vivo, dnIKK2-Treg-EV prolonged kidney allograft survival. DnIKK2-Treg-derived EV could be a tool for manipulating the immune system and for discovering novel potential immunosuppressive molecules in the context of allotransplantation. Twit Text FOAVip Extracellular vesicles derived from T regulatory cells suppress T cell proliferation and prolong allograft survival ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28912528 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28912528 #FOAvip English Wikipedia <ref>{{Cite pmid|28912528 }}</ref> Extracellular vesicles derived from T regulatory cells suppress T cell proliferation and prolong allograft survival #MMPMID28912528 Aiello S ; Rocchetta F ; Longaretti L ; Faravelli S ; Todeschini M ; Cassis L ; Pezzuto F ; Tomasoni S ; Azzollini N ; Mister M ; Mele C ; Conti S ; Breno M ; Remuzzi G ; Noris M ; Benigni A Sci Rep 2017[Sep]; 7 (1 ): 11518 PMID28912528 show ga We have previously shown that rat allogeneic DC, made immature by adenoviral gene transfer of the dominant negative form of IKK2, gave rise in-vitro to a unique population of CD4(+)CD25(-) regulatory T cells (dnIKK2-Treg). These cells inhibited Tcell response in-vitro, without needing cell-to-cell contact, and induced kidney allograft survival prolongation in-vivo. Deep insight into the mechanisms behind dnIKK2-Treg-induced suppression of Tcell proliferation remained elusive. Here we document that dnIKK2-Treg release extracellular vesicles (EV) riched in exosomes, fully accounting for the cell-contact independent immunosuppressive activity of parent cells. DnIKK2-Treg-EV contain a unique molecular cargo of specific miRNAs and iNOS, which, once delivered into target cells, blocked cell cycle progression and induced apoptosis. DnIKK2-Treg-EV-exposed T cells were in turn converted into regulatory cells. Notably, when administered in-vivo, dnIKK2-Treg-EV prolonged kidney allograft survival. DnIKK2-Treg-derived EV could be a tool for manipulating the immune system and for discovering novel potential immunosuppressive molecules in the context of allotransplantation. |*Immune Tolerance [MESH] |Allografts/*physiology [MESH] |Animals [MESH] |Extracellular Vesicles/*metabolism [MESH] |Immunosuppressive Agents/*metabolism [MESH] |Rats [MESH]Extracellular vesicles derived from T regulatory cells suppress T cell(epmc).pdf DeepDyve Pubget Overpricing