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10.1016/j.stemcr.2017.07.022 http://scihub22266oqcxt.onion/10.1016/j.stemcr.2017.07.022 C5599247!5599247 !28844659     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28844659 &cmd=llinks): Failed to open stream: HTTP request failed! 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Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors |pdf=|usr=}}{{28844659 }} gab.com Text Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors JO: Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=28844659 #FOAvip Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited blindness. However, humans depend more upon cone photoreceptors that are required for daylight, color, and high-acuity vision. Indeed, macular retinopathies involving loss of cones are leading causes of blindness. An essential step for developing stem cell-based therapies for maculopathies is the ability to generate transplantable human cones from renewable sources. Here, we report a modified 2D/3D protocol for generating hPSC-derived neural retinal vesicles with well-formed ONL-like structures containing cones and rods bearing inner segments and connecting cilia, nascent outer segments, and presynaptic structures. This differentiation system recapitulates human photoreceptor development, allowing the isolation and transplantation of a pure population of stage-matched cones. Purified human long/medium cones survive and become incorporated within the adult mouse retina, supporting the potential of photoreceptor transplantation for treating retinal degeneration. Twit Text FOAVip Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors ????Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=28844659 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28844659 #FOAvip English Wikipedia <ref>{{Cite pmid|28844659 }}</ref> Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors #MMPMID28844659 Gonzalez-Cordero A ; Kruczek K ; Naeem A ; Fernando M ; Kloc M ; Ribeiro J ; Goh D ; Duran Y ; Blackford SJI ; Abelleira-Hervas L ; Sampson RD ; Shum IO ; Branch MJ ; Gardner PJ ; Sowden JC ; Bainbridge JWB ; Smith AJ ; West EL ; Pearson RA ; Ali RR Stem Cell Reports 2017[Sep]; 9 (3 ): 820-837 PMID28844659 show ga Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited blindness. However, humans depend more upon cone photoreceptors that are required for daylight, color, and high-acuity vision. Indeed, macular retinopathies involving loss of cones are leading causes of blindness. An essential step for developing stem cell-based therapies for maculopathies is the ability to generate transplantable human cones from renewable sources. Here, we report a modified 2D/3D protocol for generating hPSC-derived neural retinal vesicles with well-formed ONL-like structures containing cones and rods bearing inner segments and connecting cilia, nascent outer segments, and presynaptic structures. This differentiation system recapitulates human photoreceptor development, allowing the isolation and transplantation of a pure population of stage-matched cones. Purified human long/medium cones survive and become incorporated within the adult mouse retina, supporting the potential of photoreceptor transplantation for treating retinal degeneration. |Adaptor Proteins, Signal Transducing/metabolism [MESH] |Animals [MESH] |Cell Differentiation [MESH] |Cells, Cultured [MESH] |Disease Models, Animal [MESH] |Human Embryonic Stem Cells/cytology/ultrastructure [MESH] |Humans [MESH] |Pluripotent Stem Cells/*cytology/metabolism [MESH] |Retinal Cone Photoreceptor Cells/*cytology/*transplantation [MESH] |Retinal Degeneration/pathology/therapy [MESH]Recapitulation of Human Retinal Development from Human Pluripotent Ste(epmc).pdf DeepDyve Pubget Overpricing