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10.1097/MD.0000000000004764 http://scihub22266oqcxt.onion/10.1097/MD.0000000000004764 C5599210!5599210!27611934     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Medicine+(Baltimore) 2016 ; 95 (Suppl 1): ä Nephropedia Template TP {{tp|p=27611934|t=2016. Cancer stem cells: understanding tumor hierarchy and heterogeneity |pdf=|usr=}}{{27611934}} gab.com Text Cancer stem cells: understanding tumor hierarchy and heterogeneity JO: Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=27611934 #FOAvip Heterogeneity within and between tumors is a well-known phenomenon that greatly complicates the diagnosis and treatment of cancer. A large body of research indicates that heterogeneity develops through time as tumor-initiating stem cells, also known as cancer stem cells (CSCs), evolve genetic or epigenetic alterations that allow them to differentiate into multiple tumor cell types. Similar to normal stem cells, CSCs can self-renew and possess long-term repopulation potential. However, unlike normal stem cells, CSCs are not subject to the usual controls that limit growth. Different models have been postulated to explain the heterogeneity of tumors, but it is widely agreed that interactions between tumor cells and their microenvironment create niches that promote CSC properties and enable their survival. Within the microenvironment, CSC self-renewal, replication, and differentiation are postulated to produce a hierarchy of cells constituting the tumor mass. Increased understanding of the factors that create and contribute to tumor heterogeneity may support the design of therapies that affect CSC function and their microenvironments. Twit Text FOAVip Cancer stem cells: understanding tumor hierarchy and heterogeneity ????Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=27611934 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27611934 #FOAvip English Wikipedia <ref>{{Cite pmid|27611934}}</ref> Cancer stem cells: understanding tumor hierarchy and heterogeneity #MMPMID27611934 Rich JN Medicine (Baltimore) 2016[Sep]; 95 (Suppl 1): ä PMID27611934show ga Heterogeneity within and between tumors is a well-known phenomenon that greatly complicates the diagnosis and treatment of cancer. A large body of research indicates that heterogeneity develops through time as tumor-initiating stem cells, also known as cancer stem cells (CSCs), evolve genetic or epigenetic alterations that allow them to differentiate into multiple tumor cell types. Similar to normal stem cells, CSCs can self-renew and possess long-term repopulation potential. However, unlike normal stem cells, CSCs are not subject to the usual controls that limit growth. Different models have been postulated to explain the heterogeneity of tumors, but it is widely agreed that interactions between tumor cells and their microenvironment create niches that promote CSC properties and enable their survival. Within the microenvironment, CSC self-renewal, replication, and differentiation are postulated to produce a hierarchy of cells constituting the tumor mass. Increased understanding of the factors that create and contribute to tumor heterogeneity may support the design of therapies that affect CSC function and their microenvironments. äCancer stem cells: understanding tumor hierarchy and heterogeneity (epmc).pdf DeepDyve Pubget Overpricing