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10.1007/s11892-014-0573-2 http://scihub22266oqcxt.onion/10.1007/s11892-014-0573-2 C5599150!5599150!25620405     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Diab+Rep 2015 ; 15 (2): 573 Nephropedia Template TP {{tp|p=25620405|t=2015. From pathobiology to the Targeting of Pericytes for the Treatment of Diabetic Retinopathy |pdf=|usr=}}{{25620405}} gab.com Text From pathobiology to the Targeting of Pericytes for the Treatment of Diabetic Retinopathy JO: Curr Diab Rep http://www.kidney.de/pget.php?&tw=1&pmid=25620405 #FOAvip Pericytes, the mural cells that constitute the capillaries along with endothelial cells, have long been associated with the pathobiology of diabetic retinopathy; however, therapeutic implications of this association remain largely unexplored. Pericytes appear to be highly susceptible to the metabolic challenges associated with a diabetic environment and there is substantial evidence that their loss may contribute to microvascular instability leading to the formation of microaneurysms, microhemorrhages, acellular capillaries, and capillary non-perfusion. Since pericytes are strategically located at the interface between the vascular and neural components of the retina, they offer extraordinary opportunities for therapeutic interventions in diabetic retinopathy. Moreover, the availability of novel imaging methodologies now allows for the in vivo visualization of pericytes, enabling a new generation of clinical trials that use pericyte tracking as clinical endpoints. The recognition of multiple signaling mechanisms involved in pericyte development and survival should allow for a renewed interest in pericytes as a therapeutic target for diabetic retinopathy. Twit Text FOAVip From pathobiology to the Targeting of Pericytes for the Treatment of Diabetic Retinopathy ????Curr Diab Rep http://www.kidney.de/pget.php?&tw=1&pmid=25620405 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25620405 #FOAvip English Wikipedia <ref>{{Cite pmid|25620405}}</ref> From pathobiology to the Targeting of Pericytes for the Treatment of Diabetic Retinopathy #MMPMID25620405 Arboleda-Velasquez JF; Valdez C; Marko CK; D'Amore PA Curr Diab Rep 2015[Feb]; 15 (2): 573 PMID25620405show ga Pericytes, the mural cells that constitute the capillaries along with endothelial cells, have long been associated with the pathobiology of diabetic retinopathy; however, therapeutic implications of this association remain largely unexplored. Pericytes appear to be highly susceptible to the metabolic challenges associated with a diabetic environment and there is substantial evidence that their loss may contribute to microvascular instability leading to the formation of microaneurysms, microhemorrhages, acellular capillaries, and capillary non-perfusion. Since pericytes are strategically located at the interface between the vascular and neural components of the retina, they offer extraordinary opportunities for therapeutic interventions in diabetic retinopathy. Moreover, the availability of novel imaging methodologies now allows for the in vivo visualization of pericytes, enabling a new generation of clinical trials that use pericyte tracking as clinical endpoints. The recognition of multiple signaling mechanisms involved in pericyte development and survival should allow for a renewed interest in pericytes as a therapeutic target for diabetic retinopathy. äFrom pathobiology to the Targeting of Pericytes for the Treatment of D(epmc).pdf DeepDyve Pubget Overpricing