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2015 ; 2
(ä): 46-55
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Protective effects of hesperidin on oxidative stress, dyslipidaemia and
histological changes in iron-induced hepatic and renal toxicity in rats
#MMPMID28962336
Pari L
; Karthikeyan A
; Karthika P
; Rathinam A
Toxicol Rep
2015[]; 2
(ä): 46-55
PMID28962336
show ga
The present study was to evaluate the protective role of hesperidin (HDN) against
iron-induced hepatic and renal toxicity in rats. Administration of iron (30 mg/kg
body weight) intraperitoneally for 10 days, the levels of serum hepatic markers,
renal functional markers, lipid profile, lipid peroxidation markers and iron
concentration in blood were significantly (p < 0.05) increased. The toxic effect
of iron was also indicated by significant (p < 0.05) decrease in the levels of
plasma, liver and kidney of enzymatic and non-enzymatic antioxidants.
Administration of hesperidin at different doses (20, 40 and 80 mg/kg body weight)
significantly (p < 0.05) reversed the levels of serum hepatic markers, renal
functional markers, lipid profile, lipid peroxidation markers, restored the
levels of hepatic, renal enzymatic antioxidants and non-enzymatic antioxidants
with decrease in iron concentration in blood. Hesperidin at a dose of 80 mg/kg
body weight exhibits significant protection on hepatic and renal when compared
with other two doses (20 and 40 mg/kg body weight). All these changes were
corroborating by histological observations of liver and kidney. This study
demonstrated the protective role of hesperidin in reducing toxic effects of iron
in experimental rats.