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2015 ; 2
(ä): 775-784
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Sub-chronic exposure to fipronil induced oxidative stress, biochemical and
histopathological changes in the liver and kidney of male albino rats
#MMPMID28962413
Mossa AH
; Swelam ES
; Mohafrash SMM
Toxicol Rep
2015[]; 2
(ä): 775-784
PMID28962413
show ga
Fipronil (FPN) is a broad-spectrum N-phenylpyrazole insecticide and has been used
in agriculture and public health since the mid-1990s. The present study was
designed to investigate the adverse effects of sub-chronic exposure to the FPN on
the liver and kidney of male rats at three concentrations 0.1, 1 and 10 mg/L in
drinking water for 45 days. Serum aspartate aminotransferases (AST), alanine
aminotransferases (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase
(LDH) activity and levels of uric acid, creatinine and total protein were
significantly increased in FPN-treated rats. Oxidative stress biomarkers such as
superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx),
glutathione-S-transferase (GST) and glutathione reduced (GSH) were significantly
decreased, while lipid peroxidation (LPO) was significantly increased in treating
rats in a concentration dependent manner. FPN caused histopathological
alterations in liver and kidney of male rats. From our results, it can be
concluded that FPN induced lipid peroxidation, oxidative stress, liver, and
kidney injury in rats. These pathophysiological changes in liver and kidney
tissues could be due to the toxic effect of FPN that associated with a generation
of free radicals.