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2015 ; 2
(ä): 1391-1395
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English Wikipedia
Glycogen synthase kinase-3? inhibitor ameliorates imbalance of connexin 43 in an
acute kidney injury model
#MMPMID28962480
Wang Y
; Tong K
Toxicol Rep
2015[]; 2
(ä): 1391-1395
PMID28962480
show ga
This study was designed to evaluate whether glycogen synthase kinase-3? (GSK-3?)
inhibitor, 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-8) induced the
the expression of connexin 43 (Cx43) to protect against renal
ischemia-reperfusion (I/R) injury (RI/RI) in rats. Rats were subjected to 45 min
ischemia followed 2 h reperfusion with TDZD-8 (1 mg/kg) for 5 min prior to
reperfusion. The results indicated that TDZD-8 improved the recovery of renal
function, reduced oxidative stress and inflammation injury, and upregulated the
expression of (Cx43) as compared to I/R group. Therefore, our study demonstrated
that TDZD-8 provided a protection to the kidney against I/R injury in rats
through inducing the expression of (Cx43).