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10.4103/ijo.IJO_1003_16

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suck abstract from ncbi


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pmid28820169
      Indian+J+Ophthalmol 2017 ; 65 (8 ): 758-760
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  • Aflibercept for recurrent or recalcitrant polypoidal choroidal vasculopathy in Indian eyes: Early experience #MMPMID28820169
  • Bansal A ; Bhende M ; Sharma T ; Bhende P ; Mukherjee S
  • Indian J Ophthalmol 2017[Aug]; 65 (8 ): 758-760 PMID28820169 show ga
  • Treatment guidelines for symptomatic polypoidal choroidal vasculopathy (PCV) have been described, but the management of recurrent or recalcitrant PCV is a challenge. The newer anti-vascular endothelial growth factor: aflibercept has shown promise in the treatment of both treatment naive and recalcitrant PCV in studies outside India. We present the minimum 6 months results of intravitreal aflibercept in recurrent and recalcitrant PCV in Indian eyes after multiple injections of bevacizumab/ranibizumab with or without photodynamic therapy. Of 10 eyes, 7 resolved of which 4 recurred needing continued aflibercept. Three of the ten eyes did not show a response. To the best of our knowledge, this is the first report from India in this challenging situation.
  • |Aged [MESH]
  • |Aged, 80 and over [MESH]
  • |Choroid Diseases/diagnosis/*drug therapy [MESH]
  • |Choroid/*blood supply [MESH]
  • |Dose-Response Relationship, Drug [MESH]
  • |Female [MESH]
  • |Fluorescein Angiography [MESH]
  • |Follow-Up Studies [MESH]
  • |Fundus Oculi [MESH]
  • |Humans [MESH]
  • |Intravitreal Injections [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Polyps/diagnosis/*drug therapy [MESH]
  • |Receptors, Vascular Endothelial Growth Factor/*administration & dosage/antagonists & inhibitors [MESH]
  • |Recombinant Fusion Proteins/*administration & dosage [MESH]
  • |Recurrence [MESH]
  • |Retrospective Studies [MESH]
  • |Time Factors [MESH]
  • |Tomography, Optical Coherence [MESH]
  • |Treatment Outcome [MESH]


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