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2017 ; 9
(1
): 20-26
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Kidney remote ischemic preconditioning as a novel strategy to explore the
accurate protective mechanisms underlying remote ischemic preconditioning
#MMPMID28932492
Tuorkey MJ
Interv Med Appl Sci
2017[Mar]; 9
(1
): 20-26
PMID28932492
show ga
INTRODUCTION: This study reports a novel strategy for investigating the key
factors responsible for the protective effect of remote ischemic preconditioning
(RIPC) against renal ischemia-reperfusion (IR) injury, which remains the leading
cause of the acute kidney injury that increase the morbidity and mortality in
patients with renal impairment. METHODS: The renal blood flow of the right
kidneys in kidney remote ischemic preconditioning (KRIPC) group was occluded for
20 min. After 48 h, the renal blood flow of the left kidneys of both KRIPC and
IPC groups was occluded for 30 min, and mice were dissected after 7 days of the
last surgery. Blood samples were analyzed by an animal blood counter. The levels
of creatinine, urea nitrogen, lipid peroxidation, nitric oxide (NO), and
high-density lipoproteins (HDLs) were estimated in the plasma of mice. Kidney
slices were stained with 2% triphenyltetrazolium chloride (TTC) to estimate the
renal infarction. RESULTS: Unlike KRIPC group, data from IPC group revealed a
massive reduction in neutrophils count, a significant increase in creatinine,
urea nitrogen, and HDLs levels, and an increase in the renal infarction compared
with control group. CONCLUSION: This is the first study demonstrating KRIPC as a
novel and applicable model with the goal of defining the accurate protective
mechanisms underlying RIPC against IR injury.
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