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2017 ; 7
(1
): 11472
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Calcitriol reduces kidney development disorders in rats provoked by losartan
administration during lactation
#MMPMID28904363
de Almeida LF
; Francescato HDC
; da Silva CGA
; Costa RS
; Coimbra TM
Sci Rep
2017[Sep]; 7
(1
): 11472
PMID28904363
show ga
Calcitriol has important effects on cellular differentiation and proliferation,
as well as on the regulation of the renin gene. Disturbances in renal development
can be observed in rats exposed to angiotensin II (AngII) antagonists during
lactation period. The lack of tubular differentiation in losartan-treated rats
can affect calcitriol uptake. This study evaluated the effect of calcitriol
administration in renal development disturbances in rats provoked by losartan
(AngII type 1 receptor antagonist) administration during lactation. Animals
exposed to losartan presented higher albuminuria, systolic blood pressure,
increased sodium and potassium fractional excretion, and decreased glomerular
filtration rate compared to controls. These animals also showed a decreased
glomerular area and a higher interstitial relative area from the renal cortex,
with increased expression of fibronectin, alpha-SM-actin, vimentin, and p-JNK;
and an increased number of macrophages, p-p38, PCNA and decreased cubilin
expression. Increased urinary excretion of MCP-1 and TGF-? was also observed. All
these alterations were less intense in the losartan?+?calcitriol group.The
animals treated with calcitriol showed an improvement in cellular
differentiation, and in renal function and structure. This effect was associated
with reduction of cell proliferation and inflammation.
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