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10.1038/s41467-017-00454-2 http://scihub22266oqcxt.onion/10.1038/s41467-017-00454-2 C5597594!5597594 !28904350     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28904350 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (1 ): 530 Nephropedia Template TP {{tp|p=28904350 |t=2017. Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells |pdf=|usr=}}{{28904350 }} gab.com Text Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28904350 #FOAvip Post-transcriptional regulation of cellular mRNA is essential for protein synthesis. Here we describe the importance of mRNA translational repression and mRNA subcellular location for protein expression during B lymphocyte activation and the DNA damage response. Cytoplasmic RNA granules are formed upon cell activation with mitogens, including stress granules that contain the RNA binding protein Tia1. Tia1 binds to a subset of transcripts involved in cell stress, including p53 mRNA, and controls translational silencing and RNA granule localization. DNA damage promotes mRNA relocation and translation in part due to dissociation of Tia1 from its mRNA targets. Upon DNA damage, p53 mRNA is released from stress granules and associates with polyribosomes to increase protein synthesis in a CAP-independent manner. Global analysis of cellular mRNA abundance and translation indicates that this is an extended ATM-dependent mechanism to increase protein expression of key modulators of the DNA damage response.Sequestering mRNA in cytoplasmic stress granules is a mechanism for translational repression. Here the authors find that p53 mRNA, present in stress granules in activated B lymphocytes, is released upon DNA damage and is translated in a CAP-independent manner. Twit Text FOAVip Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28904350 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28904350 #FOAvip English Wikipedia <ref>{{Cite pmid|28904350 }}</ref> Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells #MMPMID28904350 Díaz-Muñoz MD ; Kiselev VY ; Le Novère N ; Curk T ; Ule J ; Turner M Nat Commun 2017[Sep]; 8 (1 ): 530 PMID28904350 show ga Post-transcriptional regulation of cellular mRNA is essential for protein synthesis. Here we describe the importance of mRNA translational repression and mRNA subcellular location for protein expression during B lymphocyte activation and the DNA damage response. Cytoplasmic RNA granules are formed upon cell activation with mitogens, including stress granules that contain the RNA binding protein Tia1. Tia1 binds to a subset of transcripts involved in cell stress, including p53 mRNA, and controls translational silencing and RNA granule localization. DNA damage promotes mRNA relocation and translation in part due to dissociation of Tia1 from its mRNA targets. Upon DNA damage, p53 mRNA is released from stress granules and associates with polyribosomes to increase protein synthesis in a CAP-independent manner. Global analysis of cellular mRNA abundance and translation indicates that this is an extended ATM-dependent mechanism to increase protein expression of key modulators of the DNA damage response.Sequestering mRNA in cytoplasmic stress granules is a mechanism for translational repression. Here the authors find that p53 mRNA, present in stress granules in activated B lymphocytes, is released upon DNA damage and is translated in a CAP-independent manner. |3' Untranslated Regions [MESH] |Animals [MESH] |Ataxia Telangiectasia Mutated Proteins/genetics/metabolism [MESH] |B-Lymphocytes/drug effects/*physiology [MESH] |DNA Damage [MESH] |Etoposide/pharmacology [MESH] |Gene Expression Regulation [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Lymphocyte Activation/physiology [MESH] |Mice, Inbred C57BL [MESH] |Protein Biosynthesis/drug effects [MESH] |RNA, Messenger/*metabolism [MESH] |T-Cell Intracellular Antigen-1/genetics/*metabolism [MESH]Tia1 dependent regulation of mRNA subcellular location and translation(epmc).pdf DeepDyve Pubget Overpricing