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10.1038/s41598-017-11553-x http://scihub22266oqcxt.onion/10.1038/s41598-017-11553-x C5597580!5597580 !28904359     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28904359 &cmd=llinks): Failed to open stream: HTTP request failed! 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Structured illumination microscopy and automatized image processing as a rapid diagnostic tool for podocyte effacement |pdf=|usr=}}{{28904359 }} gab.com Text Structured illumination microscopy and automatized image processing as a rapid diagnostic tool for podocyte effacement JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28904359 #FOAvip The morphology of podocyte foot processes is obligatory for renal function. Here we describe a method for the superresolution-visualization of podocyte foot processes using structured illumination microscopy of the slit diaphragm, which before has only been achieved by electron microscopy. As a proof of principle, we measured a mean foot process width of 0.249?±?0.068?µm in healthy kidneys and a significant higher mean foot process width of 0.675?±?0.256?µm in minimal change disease patients indicating effacement of foot processes. We then hypothesized that the slit length per glomerular capillary surface area (slit diaphragm density) could be used as an equivalent for the diagnosis of effacement. Using custom-made software we measured a mean value of 3.10?±?0.27?µm(-1) in healthy subjects and 1.83?±?0.49?µm(-1) in the minimal change disease patients. As foot process width was highly correlated with slit diaphragm density (R(2)?=?0.91), we concluded that our approach is a valid method for the diagnosis of foot process effacement. In summary, we present a new technique to quantify podocyte damage, which combines superresolution microscopy with automatized image processing. Due to its diverse advantages, we propose this technique to be included into routine diagnostics of glomerular histopathology. Twit Text FOAVip Structured illumination microscopy and automatized image processing as a rapid diagnostic tool for podocyte effacement ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28904359 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28904359 #FOAvip English Wikipedia <ref>{{Cite pmid|28904359 }}</ref> Structured illumination microscopy and automatized image processing as a rapid diagnostic tool for podocyte effacement #MMPMID28904359 Siegerist F ; Ribback S ; Dombrowski F ; Amann K ; Zimmermann U ; Endlich K ; Endlich N Sci Rep 2017[Sep]; 7 (1 ): 11473 PMID28904359 show ga The morphology of podocyte foot processes is obligatory for renal function. Here we describe a method for the superresolution-visualization of podocyte foot processes using structured illumination microscopy of the slit diaphragm, which before has only been achieved by electron microscopy. As a proof of principle, we measured a mean foot process width of 0.249?±?0.068?µm in healthy kidneys and a significant higher mean foot process width of 0.675?±?0.256?µm in minimal change disease patients indicating effacement of foot processes. We then hypothesized that the slit length per glomerular capillary surface area (slit diaphragm density) could be used as an equivalent for the diagnosis of effacement. Using custom-made software we measured a mean value of 3.10?±?0.27?µm(-1) in healthy subjects and 1.83?±?0.49?µm(-1) in the minimal change disease patients. As foot process width was highly correlated with slit diaphragm density (R(2)?=?0.91), we concluded that our approach is a valid method for the diagnosis of foot process effacement. In summary, we present a new technique to quantify podocyte damage, which combines superresolution microscopy with automatized image processing. Due to its diverse advantages, we propose this technique to be included into routine diagnostics of glomerular histopathology. |*Image Processing, Computer-Assisted/methods [MESH] |*Microscopy/methods [MESH] |Automation [MESH] |Biomarkers [MESH] |Humans [MESH] |Imaging, Three-Dimensional [MESH] |Kidney Diseases/metabolism/pathology [MESH] |Microscopy, Electron [MESH] |Molecular Imaging/*methods [MESH]Structured illumination microscopy and automatized image processing as(epmc).pdf DeepDyve Pubget Overpricing