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10.1189/jlb.3HI1016-438RR http://scihub22266oqcxt.onion/10.1189/jlb.3HI1016-438RR C5597515!5597515 !28235772     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28235772 &cmd=llinks): Failed to open stream: HTTP request failed! 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Frontline Science: Shh production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma |pdf=|usr=}}{{28235772 }} gab.com Text Frontline Science: Shh production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma JO: J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=28235772 #FOAvip The pathophysiology of allergic asthma is driven by Th2 immune responses after aeroallergen inhalation. The mechanisms that initiate, potentiate, and regulate airway allergy are incompletely characterized. We have shown that Hh signaling to T cells, via downstream Gli transcription factors, enhances T cell conversion to a Th2 phenotype. In this study, we showed for the first time, to our knowledge, that Gli-dependent transcription is activated in T cells in vivo during murine AAD, a model for the immunopathology of asthma, and that genetic repression of Gli signaling in T cells decreases the differentiation and recruitment of Th2 cells to the lung. T cells were not the only cells that expressed activated Gli during AAD. A substantial proportion of eosinophils and lung epithelial cells, both central mediators of the immunopathology of asthma, also underwent Hh/Gli signaling. Finally, Shh increased Il-4 expression in eosinophils. We therefore propose that Hh signaling during AAD is complex, involving multiple cell types, signaling in an auto- or paracrine fashion. Improved understanding of the role of this major morphogenetic pathway in asthma may give rise to new drug targets for this chronic condition. Twit Text FOAVip Frontline Science: Shh production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma ????J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=28235772 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28235772 #FOAvip English Wikipedia <ref>{{Cite pmid|28235772 }}</ref> Frontline Science: Shh production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma #MMPMID28235772 Standing ASI ; Yánez DC ; Ross R ; Crompton T ; Furmanski AL J Leukoc Biol 2017[Oct]; 102 (4 ): 965-976 PMID28235772 show ga The pathophysiology of allergic asthma is driven by Th2 immune responses after aeroallergen inhalation. The mechanisms that initiate, potentiate, and regulate airway allergy are incompletely characterized. We have shown that Hh signaling to T cells, via downstream Gli transcription factors, enhances T cell conversion to a Th2 phenotype. In this study, we showed for the first time, to our knowledge, that Gli-dependent transcription is activated in T cells in vivo during murine AAD, a model for the immunopathology of asthma, and that genetic repression of Gli signaling in T cells decreases the differentiation and recruitment of Th2 cells to the lung. T cells were not the only cells that expressed activated Gli during AAD. A substantial proportion of eosinophils and lung epithelial cells, both central mediators of the immunopathology of asthma, also underwent Hh/Gli signaling. Finally, Shh increased Il-4 expression in eosinophils. We therefore propose that Hh signaling during AAD is complex, involving multiple cell types, signaling in an auto- or paracrine fashion. Improved understanding of the role of this major morphogenetic pathway in asthma may give rise to new drug targets for this chronic condition. |Animals [MESH] |Asthma/*immunology/pathology [MESH] |Autocrine Communication/genetics/immunology [MESH] |Disease Models, Animal [MESH] |Hedgehog Proteins/genetics/*immunology [MESH] |Interleukin-4/genetics/immunology [MESH] |Lung/*immunology/pathology [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Paracrine Communication/genetics/immunology [MESH] |Signal Transduction/genetics/*immunology [MESH] |Th2 Cells/*immunology/pathology [MESH]Frontline Science: Shh production and Gli signaling is activated in vi(epmc).pdf DeepDyve Pubget Overpricing