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2017 ; 12
(9
): e0184764
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Association between E/eŽ ratio and fluid overload in patients with predialysis
chronic kidney disease
#MMPMID28902883
Kim JS
; Yang JW
; Yoo JS
; Choi SO
; Han BG
PLoS One
2017[]; 12
(9
): e0184764
PMID28902883
show ga
BACKGROUND: Chronic fluid overload is common in patients with chronic kidney
disease (CKD) and can with time lead to diastolic dysfunction and heart failure.
We investigated whether markers of fluid status, such as NT-proBNP and
bioimpedance spectroscopy (BIS), can predict echocardiographic findings of
diastolic dysfunction in non-dialysis CKD5 patients. METHODS: BIS,
echocardiography, and measurement of serum NT-proBNP were performed in patients
with non-dialysis CKD stage 5 at a single study visit. E/eŽ ratio reflect mean LV
diastolic pressure and a ratio greater than 15 was used as a definition of
diastolic dysfunction. RESULTS: Eighty-four patients were analyzed. Forty-six
patients (54.76%) had E/eŽ ratio ?15 and 38 patients (45.24%) had E/eŽ > 15
(diastolic dysfunction). Patients with E/eŽ>15 had significantly higher serum
NT-proBNP (14,650 pg/mL) than patients with to E/eŽ?15 (4,271 pg/mL) and had more
overhydration (OH), 5.1 liters compared to 2.4 liters. The cut-off values
predicting diastolic dysfunction were found to be 2,797 pg/mL for NT-proBNP and
2.45 liters for OH. CONCLUSIONS: Regular monitoring of fluid status by BIS and
NT-proBNP can be used to find patient with risk of developing diastolic
dysfunction. Treatments to correct fluid overload may reduce the risk of
developing diastolic dysfunction and improve cardiovascular outcome in patients
with CKD.