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2017 ; 12
(9
): e0183591
Nephropedia Template TP
gab.com Text
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English Wikipedia
A checklist is associated with increased quality of reporting preclinical
biomedical research: A systematic review
#MMPMID28902887
Han S
; Olonisakin TF
; Pribis JP
; Zupetic J
; Yoon JH
; Holleran KM
; Jeong K
; Shaikh N
; Rubio DM
; Lee JS
PLoS One
2017[]; 12
(9
): e0183591
PMID28902887
show ga
Irreproducibility of preclinical biomedical research has gained recent attention.
It is suggested that requiring authors to complete a checklist at the time of
manuscript submission would improve the quality and transparency of scientific
reporting, and ultimately enhance reproducibility. Whether a checklist enhances
quality and transparency in reporting preclinical animal studies, however, has
not been empirically studied. Here we searched two highly cited life science
journals, one that requires a checklist at submission (Nature) and one that does
not (Cell), to identify in vivo animal studies. After screening 943 articles, a
total of 80 articles were identified in 2013 (pre-checklist) and 2015
(post-checklist), and included for the detailed evaluation of reporting
methodological and analytical information. We compared the quality of reporting
preclinical animal studies between the two journals, accounting for differences
between journals and changes over time in reporting. We find that reporting of
randomization, blinding, and sample-size estimation significantly improved when
comparing Nature to Cell from 2013 to 2015, likely due to implementation of a
checklist. Specifically, improvement in reporting of the three methodological
information was at least three times greater when a mandatory checklist was
implemented than when it was not. Reporting the sex of animals and the number of
independent experiments performed also improved from 2013 to 2015, likely from
factors not related to a checklist. Our study demonstrates that completing a
checklist at manuscript submission is associated with improved reporting of key
methodological information in preclinical animal studies.
|*Checklist
[MESH]
|*Data Accuracy
[MESH]
|Animals
[MESH]
|Biomedical Research/*standards/statistics & numerical data
[MESH]
|Drug Evaluation, Preclinical/standards
[MESH]
|Humans
[MESH]
|Models, Animal
[MESH]
|Publications/standards/statistics & numerical data
[MESH]
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free
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