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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Oral+Maxillofac+Pathol
2017 ; 21
(2
): 229-238
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Mast cells and angiogenesis in malignant and premalignant oral lesions: An
immunohistochemical study
#MMPMID28932032
Laishram D
; Rao K
; Devi HSU
; Priya NS
; Smitha T
; Sheethal HS
J Oral Maxillofac Pathol
2017[May]; 21
(2
): 229-238
PMID28932032
show ga
INTRODUCTION AND OBJECTIVES: Angiogenesis is a complex event facilitated by
angiogenic factors released from neoplastic and host immune cells. Among host
immune cells, mast cells (MCs) may have greater significance in tumor progression
through angiogenesis. The objectives of the study were to evaluate and correlate
mast cell density (MCD) and microvessel density (MVD) in normal gingival tissue,
leukoplakia with and without dysplasia and oral squamous cell carcinoma (OSCC)
cases. MATERIALS AND METHODS: Among eighty selected cases, twenty were of normal
gingiva, twenty each of leukoplakia without and with dysplasia and twenty of
OSCC. The slides were stained with CD34 and counterstained with 0.1% toluidine
blue, followed by quantification of MCD and MVD per high-power field (×40) using
Image-Pro Express software. STATISTICAL ANALYSIS: Chi-square test and correlation
coefficient were used for statistical analysis. OBSERVATION AND RESULTS: A
statistically significant difference in the values of MVD and MCD between normal
gingival tissue, leukoplakia with and without dysplasia and OSCC (P = 0.000) was
observed. MVD and MCD showed a positive correlation between the study groups.
CONCLUSION: MVD and MCD increased significantly in cases of OSCC as compared to
leukoplakia with and without dysplasia and normal gingival tissue. It was
concluded that MCs may play a significant role in angiogenesis by releasing
pro-angiogenic and angiogenic factors which may in turn favor the progression of
premalignant lesion to a malignant one.