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10.1038/cddis.2017.389 http://scihub22266oqcxt.onion/10.1038/cddis.2017.389 C5596575!5596575 !28817116     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28817116 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2017 ; 8 (8 ): e3004 Nephropedia Template TP {{tp|p=28817116 |t=2017. Total tanshinones exhibits anti-inflammatory effects through blocking TLR4 dimerization via the MyD88 pathway |pdf=|usr=}}{{28817116 }} gab.com Text Total tanshinones exhibits anti-inflammatory effects through blocking TLR4 dimerization via the MyD88 pathway JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28817116 #FOAvip Tanshinones belong to a group of lipophilic constituents of Salvia miltiorrhiza Bunge (Danshen), which is widely used in traditional Chinese medicine. A deluge of studies demonstrated that tanshinones exert anti-inflammatory effects, but the underlying mechanisms remain unclear to date. This study investigated the anti-inflammatory effects and mechanisms of total tanshinones (TTN). TTN suppressed the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and the secretion of TNF-?, IL-6, and IL-1? in RAW264.7 cells, bone marrow-derived macrophages, and THP-1 cells. TTN attenuated the LPS-induced transcriptional activity of NF-?B and decreased I?B-? and IKK phosphorylation and NF-?B/p65 nuclear translocation. Furthermore, TTN inhibited the LPS-induced transcriptional activity of AP-1, which was induced by the reduction of JNK1/2, ERK1/2, and p38MAPK phosphorylation. TTN blocked LPS-induced Toll-like receptor 4 (TLR4) dimerization, which consequently decreased MyD88 recruitment and TAK1 phosphorylation. In addition, TTN pretreatment effectively inhibited xylene-induced ear edema and LPS-induced septic death and improved LPS-induced acute kidney injury in mice. TTN exerts anti-inflammatory effects in vitro and in vivo by blocking TLR4 dimerization to activate MyD88-TAK1-NF-?B/MAPK signaling cascades, which provide the molecular basis of the anti-inflammatory effect of Danshen and suggest that TTN is a potential agent for the treatment of inflammatory diseases. Twit Text FOAVip Total tanshinones exhibits anti-inflammatory effects through blocking TLR4 dimerization via the MyD88 pathway ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28817116 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28817116 #FOAvip English Wikipedia <ref>{{Cite pmid|28817116 }}</ref> Total tanshinones exhibits anti-inflammatory effects through blocking TLR4 dimerization via the MyD88 pathway #MMPMID28817116 Gao H ; Liu X ; Sun W ; Kang N ; Liu Y ; Yang S ; Xu QM ; Wang C ; Chen X Cell Death Dis 2017[Aug]; 8 (8 ): e3004 PMID28817116 show ga Tanshinones belong to a group of lipophilic constituents of Salvia miltiorrhiza Bunge (Danshen), which is widely used in traditional Chinese medicine. A deluge of studies demonstrated that tanshinones exert anti-inflammatory effects, but the underlying mechanisms remain unclear to date. This study investigated the anti-inflammatory effects and mechanisms of total tanshinones (TTN). TTN suppressed the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and the secretion of TNF-?, IL-6, and IL-1? in RAW264.7 cells, bone marrow-derived macrophages, and THP-1 cells. TTN attenuated the LPS-induced transcriptional activity of NF-?B and decreased I?B-? and IKK phosphorylation and NF-?B/p65 nuclear translocation. Furthermore, TTN inhibited the LPS-induced transcriptional activity of AP-1, which was induced by the reduction of JNK1/2, ERK1/2, and p38MAPK phosphorylation. TTN blocked LPS-induced Toll-like receptor 4 (TLR4) dimerization, which consequently decreased MyD88 recruitment and TAK1 phosphorylation. In addition, TTN pretreatment effectively inhibited xylene-induced ear edema and LPS-induced septic death and improved LPS-induced acute kidney injury in mice. TTN exerts anti-inflammatory effects in vitro and in vivo by blocking TLR4 dimerization to activate MyD88-TAK1-NF-?B/MAPK signaling cascades, which provide the molecular basis of the anti-inflammatory effect of Danshen and suggest that TTN is a potential agent for the treatment of inflammatory diseases. |Abietanes/isolation & purification/*pharmacology [MESH] |Animals [MESH] |Anti-Inflammatory Agents/isolation & purification/*pharmacology [MESH] |Cyclooxygenase 2/genetics/immunology [MESH] |Ear [MESH] |Edema/chemically induced/*drug therapy/genetics/immunology [MESH] |Gene Expression Regulation [MESH] |Humans [MESH] |Interleukin-1beta/genetics/immunology [MESH] |Interleukin-6/genetics/immunology [MESH] |Lipopolysaccharides/pharmacology [MESH] |Mice [MESH] |Mitogen-Activated Protein Kinases/genetics/immunology [MESH] |Myeloid Differentiation Factor 88/genetics/*immunology [MESH] |NF-KappaB Inhibitor alpha/genetics/immunology [MESH] |Nitric Oxide Synthase Type II/genetics/immunology [MESH] |Protein Multimerization [MESH] |RAW 264.7 Cells [MESH] |Salvia miltiorrhiza/*chemistry [MESH] |Sepsis/chemically induced/*drug therapy/genetics/immunology [MESH] |Signal Transduction [MESH] |THP-1 Cells [MESH] |Toll-Like Receptor 4/antagonists & inhibitors/genetics/*immunology [MESH] |Transcription Factor AP-1/genetics/immunology [MESH] |Transcription Factor RelA/genetics/immunology [MESH]Total tanshinones exhibits anti-inflammatory effects through blocking (epmc).pdf DeepDyve Pubget Overpricing