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10.1038/cddis.2017.385 http://scihub22266oqcxt.onion/10.1038/cddis.2017.385 C5596571!5596571 !28796248     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28796248 &cmd=llinks): Failed to open stream: HTTP request failed! 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Upregulation of DACT2 suppresses proliferation and enhances apoptosis of glioma cell via inactivation of YAP signaling pathway |pdf=|usr=}}{{28796248 }} gab.com Text Upregulation of DACT2 suppresses proliferation and enhances apoptosis of glioma cell via inactivation of YAP signaling pathway JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28796248 #FOAvip DACT2, one of the Dact gene family members, was shown to function as a tumor suppressor. However, its function in gliomas remains largely unknown. In this study, we investigated the role of DACT2, underlying molecular mechanisms and its clinical significance in glioma patients. Downexpression of DACT2 in gliomas compared with adjacent normal brain tissues was correlated with glioma grade and poor survival. Cox regression analysis revealed that the DACT2 is an independent prognostic indicator for glioma patients. Overexpression of DACT2 in glioma cells inhibited proliferation, cell cycle and enhanced apoptosis, sensitivity to temozolomide in vitro and suppressed tumor growth in vivo. Whereas knockdown of DACT2 induce opposite reaction. Mechanistically, overexpression of DACT2 resulted in upregulation of important signaling molecules such as p-YAP and p-?-catenin, and prevent YAP translocating into nucleus and sequestering in the cytoplasm to degrade. The study further proved that DACT2 can suppress YAP through Wnt/?-catenin signaling pathway. Collectively, these data indicate that DACT2 has a tumor suppressor function via inactivation of YAP pathway, providing a promising target for the treatment of gliomas. Twit Text FOAVip Upregulation of DACT2 suppresses proliferation and enhances apoptosis of glioma cell via inactivation of YAP signaling pathway ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28796248 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28796248 #FOAvip English Wikipedia <ref>{{Cite pmid|28796248 }}</ref> Upregulation of DACT2 suppresses proliferation and enhances apoptosis of glioma cell via inactivation of YAP signaling pathway #MMPMID28796248 Tan Y ; Li QM ; Huang N ; Cheng S ; Zhao GJ ; Chen H ; Chen S ; Tang ZH ; Zhang WQ ; Huang Q ; Cheng Y Cell Death Dis 2017[Aug]; 8 (8 ): e2981 PMID28796248 show ga DACT2, one of the Dact gene family members, was shown to function as a tumor suppressor. However, its function in gliomas remains largely unknown. In this study, we investigated the role of DACT2, underlying molecular mechanisms and its clinical significance in glioma patients. Downexpression of DACT2 in gliomas compared with adjacent normal brain tissues was correlated with glioma grade and poor survival. Cox regression analysis revealed that the DACT2 is an independent prognostic indicator for glioma patients. Overexpression of DACT2 in glioma cells inhibited proliferation, cell cycle and enhanced apoptosis, sensitivity to temozolomide in vitro and suppressed tumor growth in vivo. Whereas knockdown of DACT2 induce opposite reaction. Mechanistically, overexpression of DACT2 resulted in upregulation of important signaling molecules such as p-YAP and p-?-catenin, and prevent YAP translocating into nucleus and sequestering in the cytoplasm to degrade. The study further proved that DACT2 can suppress YAP through Wnt/?-catenin signaling pathway. Collectively, these data indicate that DACT2 has a tumor suppressor function via inactivation of YAP pathway, providing a promising target for the treatment of gliomas. |Adaptor Proteins, Signal Transducing/genetics/*metabolism [MESH] |Animals [MESH] |Apoptosis/genetics/physiology [MESH] |Blotting, Western [MESH] |Carrier Proteins/genetics/*metabolism [MESH] |Cell Cycle Proteins [MESH] |Cell Cycle/genetics/physiology [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/genetics/*physiology [MESH] |Flow Cytometry [MESH] |Fluorescent Antibody Technique [MESH] |Gene Expression Regulation, Neoplastic/genetics/physiology [MESH] |Glioma/genetics/*metabolism [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Male [MESH] |Mice [MESH] |Mice, Nude [MESH] |Neoplasm Proteins/genetics/*metabolism [MESH] |Phosphoproteins/genetics/*metabolism [MESH] |Proportional Hazards Models [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Transcription Factors [MESH] |YAP-Signaling Proteins [MESH]Upregulation of DACT2 suppresses proliferation and enhances apoptosis (epmc).pdf DeepDyve Pubget Overpricing