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10.1038/cddis.2017.359 http://scihub22266oqcxt.onion/10.1038/cddis.2017.359 C5596550!5596550 !28771223     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28771223 &cmd=llinks): Failed to open stream: HTTP request failed! 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Pigment epithelium-derived factor promotes tumor metastasis through an interaction with laminin receptor in hepatocellular carcinomas |pdf=|usr=}}{{28771223 }} gab.com Text Pigment epithelium-derived factor promotes tumor metastasis through an interaction with laminin receptor in hepatocellular carcinomas JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28771223 #FOAvip Pigment epithelium-derived factor (PEDF) has complex functions in tumor metastasis, but little is known about the roles of PEDF and its receptors in hepatocellular carcinoma (HCC). Here we found that high expression of PEDF is associated with shorter overall survival in HCC patients. Forced expression of PEDF enhanced HCC cell aggressive behavior in vitro and in vivo, whereas silencing PEDF expression reduced migration and invasion. Furthermore, PEDF expression led to changes in cell morphology and the expression of epithelial-mesenchymal transition (EMT)-related markers via ERK1/2 signaling pathway, including the upregulation of N-cadherin and slug, and the downregulation of E-cadherin in HCC cells. Our results further showed that PEDF could interact with laminin receptor (LR) and LR knockdown attenuated PEDF-induced migration, invasion and the change of EMT-related markers. More importantly, in clinical HCC specimens, we found that PEDF expression was correlated with subcellular localization of LR, and that high expression of PEDF and positive expression of LR predicted a poor prognosis. In conclusion, our results demonstrate a novel functional role of PEDF/LR axis in driving metastasis through ERK1/2-mediated EMT in HCC and provided a promising prognostic marker in HCC. Twit Text FOAVip Pigment epithelium-derived factor promotes tumor metastasis through an interaction with laminin receptor in hepatocellular carcinomas ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28771223 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28771223 #FOAvip English Wikipedia <ref>{{Cite pmid|28771223 }}</ref> Pigment epithelium-derived factor promotes tumor metastasis through an interaction with laminin receptor in hepatocellular carcinomas #MMPMID28771223 Hou J ; Ge C ; Cui M ; Liu T ; Liu X ; Tian H ; Zhao F ; Chen T ; Cui Y ; Yao M ; Li J ; Li H Cell Death Dis 2017[Aug]; 8 (8 ): e2969 PMID28771223 show ga Pigment epithelium-derived factor (PEDF) has complex functions in tumor metastasis, but little is known about the roles of PEDF and its receptors in hepatocellular carcinoma (HCC). Here we found that high expression of PEDF is associated with shorter overall survival in HCC patients. Forced expression of PEDF enhanced HCC cell aggressive behavior in vitro and in vivo, whereas silencing PEDF expression reduced migration and invasion. Furthermore, PEDF expression led to changes in cell morphology and the expression of epithelial-mesenchymal transition (EMT)-related markers via ERK1/2 signaling pathway, including the upregulation of N-cadherin and slug, and the downregulation of E-cadherin in HCC cells. Our results further showed that PEDF could interact with laminin receptor (LR) and LR knockdown attenuated PEDF-induced migration, invasion and the change of EMT-related markers. More importantly, in clinical HCC specimens, we found that PEDF expression was correlated with subcellular localization of LR, and that high expression of PEDF and positive expression of LR predicted a poor prognosis. In conclusion, our results demonstrate a novel functional role of PEDF/LR axis in driving metastasis through ERK1/2-mediated EMT in HCC and provided a promising prognostic marker in HCC. |*MAP Kinase Signaling System [MESH] |Carcinoma, Hepatocellular/genetics/*metabolism/pathology [MESH] |Cell Line, Tumor [MESH] |Cell Movement [MESH] |Eye Proteins/genetics/*metabolism [MESH] |Humans [MESH] |Liver Neoplasms/genetics/*metabolism/pathology [MESH] |Mitogen-Activated Protein Kinase 1/genetics/metabolism [MESH] |Mitogen-Activated Protein Kinase 3/genetics/metabolism [MESH] |Neoplasm Metastasis [MESH] |Neoplasm Proteins/genetics/*metabolism [MESH] |Nerve Growth Factors/genetics/*metabolism [MESH] |Receptors, Laminin/genetics/*metabolism [MESH]Pigment epithelium-derived factor promotes tumor metastasis through an(epmc).pdf DeepDyve Pubget Overpricing