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10.1111/irv.12459 http://scihub22266oqcxt.onion/10.1111/irv.12459 C5596526!5596526 !28646616     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28646616 &cmd=llinks): Failed to open stream: HTTP request failed! 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Curcumin alleviates macrophage activation and lung inflammation induced by influenza virus infection through inhibiting the NF-?B signaling pathway |pdf=|usr=}}{{28646616 }} gab.com Text Curcumin alleviates macrophage activation and lung inflammation induced by influenza virus infection through inhibiting the NF- B signaling pathway JO: Influenza Other Respir Viruses http://www.kidney.de/pget.php?&tw=1&pmid=28646616 #FOAvip BACKGROUND: Influenza A viruses (IAV) result in severe public health problems with worldwide each year. Overresponse of immune system to IAV infection leads to complications, and ultimately causing morbidity and mortality. OBJECTIVE: Curcumin has been reported to have anti-inflammatory ability. However, its molecular mechanism in immune responses remains unclear. METHODS: We detected the pro-inflammatory cytokine secretion and nuclear factor kappa-light-chain-enhancer of activated B cell (NF-?B)-related protein expression in human macrophages or mice infected by IAV with or without curcumin treatment. RESULTS: We found that the IAV infection caused a dramatic enhancement of pro-inflammatory cytokine productions of human macrophages and mice immune cells. However, curcumin treatment after IAV infection downregulated these cytokines production in a dose-dependent manner. Moreover, the NF-?B has been activated in human macrophages after IAV infection, while administration of curcumin inhibited NF-?B signaling pathway via promoting the expression of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (I?B?), and inhibiting the translocation of p65 from cytoplasm to nucleus. CONCLUSIONS: In summary, IAV infection could result in the inflammatory responses of immune cells, especially macrophages. Curcumin has the therapeutic potentials to relieve these inflammatory responses through inhibiting the NF-?B signaling pathway. Twit Text FOAVip Curcumin alleviates macrophage activation and lung inflammation induced by influenza virus infection through inhibiting the NF- B signaling pathway ????Influenza Other Respir Viruses http://www.kidney.de/pget.php?&tw=1&pmid=28646616 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28646616 #FOAvip English Wikipedia <ref>{{Cite pmid|28646616 }}</ref> Curcumin alleviates macrophage activation and lung inflammation induced by influenza virus infection through inhibiting the NF-?B signaling pathway #MMPMID28646616 Xu Y ; Liu L Influenza Other Respir Viruses 2017[Sep]; 11 (5 ): 457-463 PMID28646616 show ga BACKGROUND: Influenza A viruses (IAV) result in severe public health problems with worldwide each year. Overresponse of immune system to IAV infection leads to complications, and ultimately causing morbidity and mortality. OBJECTIVE: Curcumin has been reported to have anti-inflammatory ability. However, its molecular mechanism in immune responses remains unclear. METHODS: We detected the pro-inflammatory cytokine secretion and nuclear factor kappa-light-chain-enhancer of activated B cell (NF-?B)-related protein expression in human macrophages or mice infected by IAV with or without curcumin treatment. RESULTS: We found that the IAV infection caused a dramatic enhancement of pro-inflammatory cytokine productions of human macrophages and mice immune cells. However, curcumin treatment after IAV infection downregulated these cytokines production in a dose-dependent manner. Moreover, the NF-?B has been activated in human macrophages after IAV infection, while administration of curcumin inhibited NF-?B signaling pathway via promoting the expression of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (I?B?), and inhibiting the translocation of p65 from cytoplasm to nucleus. CONCLUSIONS: In summary, IAV infection could result in the inflammatory responses of immune cells, especially macrophages. Curcumin has the therapeutic potentials to relieve these inflammatory responses through inhibiting the NF-?B signaling pathway. |Animals [MESH] |Anti-Inflammatory Agents/administration & dosage/*pharmacology [MESH] |Curcumin/administration & dosage/*pharmacology [MESH] |Cytokines/drug effects/genetics/metabolism [MESH] |Dogs [MESH] |Down-Regulation [MESH] |Humans [MESH] |Influenza A Virus, H1N1 Subtype/drug effects/immunology [MESH] |Macrophage Activation/*drug effects [MESH] |Macrophages/drug effects/immunology [MESH] |Madin Darby Canine Kidney Cells [MESH] |Mice [MESH] |NF-kappa B/antagonists & inhibitors/genetics/*metabolism [MESH] |Orthomyxoviridae Infections/drug therapy/*immunology/metabolism/virology [MESH] |Pneumonia/drug therapy/immunology [MESH]Curcumin alleviates macrophage activation and lung inflammation induce(epmc).pdf DeepDyve Pubget Overpricing