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2017 ; 11
(5
): 372-393
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gab.com Text
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The hidden burden of influenza: A review of the extra-pulmonary complications of
influenza infection
#MMPMID28745014
Sellers SA
; Hagan RS
; Hayden FG
; Fischer WA 2nd
Influenza Other Respir Viruses
2017[Sep]; 11
(5
): 372-393
PMID28745014
show ga
Severe influenza infection represents a leading cause of global morbidity and
mortality. Although influenza is primarily considered a viral infection that
results in pathology limited to the respiratory system, clinical reports suggest
that influenza infection is frequently associated with a number of clinical
syndromes that involve organ systems outside the respiratory tract. A
comprehensive MEDLINE literature review of articles pertaining to extra-pulmonary
complications of influenza infection, using organ-specific search terms, yielded
218 articles including case reports, epidemiologic investigations, and autopsy
studies that were reviewed to determine the clinical involvement of other organs.
The most frequently described clinical entities were viral myocarditis and viral
encephalitis. Recognition of these extra-pulmonary complications is critical to
determining the true burden of influenza infection and initiating organ-specific
supportive care.