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10.7150/thno.20861 http://scihub22266oqcxt.onion/10.7150/thno.20861 C5596433!5596433 !28912885     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28912885 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Theranostics 2017 ; 7 (14 ): 3415-3431 Nephropedia Template TP {{tp|p=28912885 |t=2017. Brusatol-Mediated Inhibition of c-Myc Increases HIF-1? Degradation and Causes Cell Death in Colorectal Cancer under Hypoxia |pdf=|usr=}}{{28912885 }} gab.com Text Brusatol-Mediated Inhibition of c-Myc Increases HIF-1 Degradation and Causes Cell Death in Colorectal Cancer under Hypoxia JO: Theranostics http://www.kidney.de/pget.php?&tw=1&pmid=28912885 #FOAvip HIF-1 (hypoxia-inducible factor-1) regulates the expression of ~100 genes involved in angiogenesis, metastasis, tumor growth, chemoresistance and radioresistance, underscoring the growing interest in targeting HIF-1 for cancer control. In the present study, we investigated the molecular mechanisms underlying brusatol-induced HIF-1? degradation and cell death in colorectal cancer under hypoxia (0.5% O(2)). Under hypoxia, pretreatment of cancer cells with brusatol increased HIF-1? degradation and cancer cell death in a dose-dependent manner. This effect was mediated by activation of prolyl hydroxylases (PHDs), as evidenced by the block of brusatol-induced HIF-1? degradation and cancer cell death by both pharmacological inhibition and siRNA-mediated knockdown of PHDs. In addition, a ferrous iron chelator (2,2'-bypyridyl) blocked brusatol-induced degradation of HIF-1? and cancer cell death in hypoxia by inhibiting PHD activation. We further found that brusatol inhibited c-Myc expression, and showed that overexpression of c-Myc prevented brusatol-induced degradation of HIF-1? and cancer cell death by increasing mitochondrial ROS production and subsequent ROS-mediated transition of ferrous iron to ferric iron. Consistent with these results, treatment of tumor-bearing mice with brusatol significantly suppressed tumor growth by promoting PHD-mediated HIF-1? degradation. Collectively, our results suggest that brusatol-mediated inhibition of c-Myc/ROS signaling pathway increases HIF-1? degradation by promoting PHD activity and induces cell death in colorectal cancer under hypoxia. Twit Text FOAVip Brusatol-Mediated Inhibition of c-Myc Increases HIF-1 Degradation and Causes Cell Death in Colorectal Cancer under Hypoxia ????Theranostics http://www.kidney.de/pget.php?&tw=1&pmid=28912885 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28912885 #FOAvip English Wikipedia <ref>{{Cite pmid|28912885 }}</ref> Brusatol-Mediated Inhibition of c-Myc Increases HIF-1? Degradation and Causes Cell Death in Colorectal Cancer under Hypoxia #MMPMID28912885 Oh ET ; Kim CW ; Kim HG ; Lee JS ; Park HJ Theranostics 2017[]; 7 (14 ): 3415-3431 PMID28912885 show ga HIF-1 (hypoxia-inducible factor-1) regulates the expression of ~100 genes involved in angiogenesis, metastasis, tumor growth, chemoresistance and radioresistance, underscoring the growing interest in targeting HIF-1 for cancer control. In the present study, we investigated the molecular mechanisms underlying brusatol-induced HIF-1? degradation and cell death in colorectal cancer under hypoxia (0.5% O(2)). Under hypoxia, pretreatment of cancer cells with brusatol increased HIF-1? degradation and cancer cell death in a dose-dependent manner. This effect was mediated by activation of prolyl hydroxylases (PHDs), as evidenced by the block of brusatol-induced HIF-1? degradation and cancer cell death by both pharmacological inhibition and siRNA-mediated knockdown of PHDs. In addition, a ferrous iron chelator (2,2'-bypyridyl) blocked brusatol-induced degradation of HIF-1? and cancer cell death in hypoxia by inhibiting PHD activation. We further found that brusatol inhibited c-Myc expression, and showed that overexpression of c-Myc prevented brusatol-induced degradation of HIF-1? and cancer cell death by increasing mitochondrial ROS production and subsequent ROS-mediated transition of ferrous iron to ferric iron. Consistent with these results, treatment of tumor-bearing mice with brusatol significantly suppressed tumor growth by promoting PHD-mediated HIF-1? degradation. Collectively, our results suggest that brusatol-mediated inhibition of c-Myc/ROS signaling pathway increases HIF-1? degradation by promoting PHD activity and induces cell death in colorectal cancer under hypoxia. |*Apoptosis [MESH] |*Proteolysis [MESH] |Animals [MESH] |Antineoplastic Agents/*pharmacology/therapeutic use [MESH] |Cell Hypoxia [MESH] |Colorectal Neoplasms/drug therapy/*metabolism [MESH] |HCT116 Cells [MESH] |HT29 Cells [MESH] |Humans [MESH] |Hypoxia-Inducible Factor 1/*metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Prolyl Hydroxylases/metabolism [MESH] |Proto-Oncogene Proteins c-myc/antagonists & inhibitors/*metabolism [MESH] |Quassins/*pharmacology/therapeutic use [MESH]Brusatol-Mediated Inhibition of c-Myc Increases HIF-1? Degradation and(epmc).pdf DeepDyve Pubget Overpricing