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10.1016/j.redox.2017.08.015 http://scihub22266oqcxt.onion/10.1016/j.redox.2017.08.015 C5596264!5596264 !28888202     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28888202 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Redox+Biol 2018 ; 14 (ä): 100-115 Nephropedia Template TP {{tp|p=28888202 |t=2018. Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis |pdf=|usr=}}{{28888202 }} gab.com Text Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis JO: Redox Biol http://www.kidney.de/pget.php?&tw=1&pmid=28888202 #FOAvip Cellular senescence is characterised by the irreversible arrest of proliferation, a pro-inflammatory secretory phenotype and evasion of programmed cell death mechanisms. We report that senescence alters cellular iron acquisition and storage and also impedes iron-mediated cell death pathways. Senescent cells, regardless of stimuli (irradiation, replicative or oncogenic), accumulate vast amounts of intracellular iron (up to 30-fold) with concomitant changes in the levels of iron homeostasis proteins. For instance, ferritin (iron storage) levels provided a robust biomarker of cellular senescence, for associated iron accumulation and for resistance to iron-induced toxicity. Cellular senescence preceded iron accumulation and was not perturbed by sustained iron chelation (deferiprone). Iron accumulation in senescent cells was driven by impaired ferritinophagy, a lysosomal process that promotes ferritin degradation and ferroptosis. Lysosomal dysfunction in senescent cells was confirmed through several markers, including the build-up of microtubule-associated protein light chain 3 (LC3-II) in autophagosomes. Impaired ferritin degradation explains the iron accumulation phenotype of senescent cells, whereby iron is effectively trapped in ferritin creating a perceived cellular deficiency. Accordingly, senescent cells were highly resistant to ferroptosis. Promoting ferritin degradation by using the autophagy activator rapamycin averted the iron accumulation phenotype of senescent cells, preventing the increase of TfR1, ferritin and intracellular iron, but failed to re-sensitize these cells to ferroptosis. Finally, the enrichment of senescent cells in mouse ageing hepatic tissue was found to accompany iron accumulation, an elevation in ferritin and mirrored our observations using cultured senescent cells. Twit Text FOAVip Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis ????Redox Biol http://www.kidney.de/pget.php?&tw=1&pmid=28888202 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28888202 #FOAvip English Wikipedia <ref>{{Cite pmid|28888202 }}</ref> Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis #MMPMID28888202 Masaldan S ; Clatworthy SAS ; Gamell C ; Meggyesy PM ; Rigopoulos AT ; Haupt S ; Haupt Y ; Denoyer D ; Adlard PA ; Bush AI ; Cater MA Redox Biol 2018[Apr]; 14 (ä): 100-115 PMID28888202 show ga Cellular senescence is characterised by the irreversible arrest of proliferation, a pro-inflammatory secretory phenotype and evasion of programmed cell death mechanisms. We report that senescence alters cellular iron acquisition and storage and also impedes iron-mediated cell death pathways. Senescent cells, regardless of stimuli (irradiation, replicative or oncogenic), accumulate vast amounts of intracellular iron (up to 30-fold) with concomitant changes in the levels of iron homeostasis proteins. For instance, ferritin (iron storage) levels provided a robust biomarker of cellular senescence, for associated iron accumulation and for resistance to iron-induced toxicity. Cellular senescence preceded iron accumulation and was not perturbed by sustained iron chelation (deferiprone). Iron accumulation in senescent cells was driven by impaired ferritinophagy, a lysosomal process that promotes ferritin degradation and ferroptosis. Lysosomal dysfunction in senescent cells was confirmed through several markers, including the build-up of microtubule-associated protein light chain 3 (LC3-II) in autophagosomes. Impaired ferritin degradation explains the iron accumulation phenotype of senescent cells, whereby iron is effectively trapped in ferritin creating a perceived cellular deficiency. Accordingly, senescent cells were highly resistant to ferroptosis. Promoting ferritin degradation by using the autophagy activator rapamycin averted the iron accumulation phenotype of senescent cells, preventing the increase of TfR1, ferritin and intracellular iron, but failed to re-sensitize these cells to ferroptosis. Finally, the enrichment of senescent cells in mouse ageing hepatic tissue was found to accompany iron accumulation, an elevation in ferritin and mirrored our observations using cultured senescent cells. |Animals [MESH] |Apoptosis/*drug effects [MESH] |Cell Survival/drug effects [MESH] |Cells, Cultured [MESH] |Cellular Senescence/*drug effects [MESH] |Cyclin-Dependent Kinase Inhibitor p16/metabolism [MESH] |Ferritins/metabolism [MESH] |Fibroblasts/cytology/metabolism [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Iron/analysis/metabolism/*toxicity [MESH] |Lysosomes/metabolism [MESH] |Mass Spectrometry [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH]Iron accumulation in senescent cells is coupled with impaired ferritin(epmc).pdf DeepDyve Pubget Overpricing