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2017 ; 10
(9
): 1396-1401
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Comparative analysis of cytomegalovirus retinitis and microvascular retinopathy
in patients with acquired immunodeficiency syndrome
#MMPMID28944199
Chen C
; Guo CG
; Meng L
; Yu J
; Xie LY
; Dong HW
; Wei WB
Int J Ophthalmol
2017[]; 10
(9
): 1396-1401
PMID28944199
show ga
AIM: To compare the clinical manifestation of cytomegalovirus (CMV) retinitis and
microvascular retinopathy (MVR) in patients with acquired immunodeficiency
syndrome (AIDS) in China. METHODS: A total of 93 consecutive patients with AIDS,
including 41 cases of CMV retinitis and 52 cases of MVR were retrospectively
reviewed. Highly active antiretroviral therapy (HAART) status was recorded. HIV
and CMV immunoassay were also tested. CD4+ T-lymphocyte count and blood CMV-DNA
test were performed in all patients. Aqueous humor CMV-DNA test was completed in
39 patients. Ophthalmological examinations including best corrected visual acuity
(BCVA, by International Standard Vision Chart), intraocular pressure (IOP),
slit-lamp biomicroscopy, indirect ophthalmoscopy were performed. RESULTS: In MVR
group, the anterior segment examination was normal in all patients with a mean
BCVA of 0.93±0.13. Blood CMV-DNA was 0 (0, 269 000) and 42 patients (80.77%) did
not receive HAART. In CMV retinitis group, 13 patients (31.71%) had anterior
segment abnormality. The mean BCVA was 0.64±0.35 and blood CMV-DNA was 3470 (0, 1
450 000). Nineteen patients (46.34%) had not received HAART. MVR group and CMV
retinitis group the positive rates of aqueous CMV-DNA were 0 and 50%,
respectively. Two patients with MVR progressed to CMV retinitis during the
follow-up period. CONCLUSION: In comparison of CMV, patients with MVR have
relatively mild visual function impairment. Careful ophthalmological examination
and close follow-up are mandatory, especially for patients who have systemic
complications, positive CMV-DNA test and without received HAART.