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2017 ; 8
(ä): 1726
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In Silico Screening of the Human Gut Metaproteome Identifies Th17-Promoting
Peptides Encrypted in Proteins of Commensal Bacteria
#MMPMID28943872
Hidalgo-Cantabrana C
; Moro-García MA
; Blanco-Míguez A
; Fdez-Riverola F
; Lourenço A
; Alonso-Arias R
; Sánchez B
Front Microbiol
2017[]; 8
(ä): 1726
PMID28943872
show ga
Scientific studies focused on the role of the human microbiome over human health
have generated billions of gigabits of genetic information during the last
decade. Nowadays integration of all this information in public databases and
development of pipelines allowing us to biotechnologically exploit this
information are urgently needed. Prediction of the potential bioactivity of the
products encoded by the human gut microbiome, or metaproteome, is the first step
for identifying proteins responsible for the molecular interaction between
microorganisms and the immune system. We have recently published the Mechanism of
Action of the Human Microbiome (MAHMI) database (http://www.mahmi.org), conceived
as a resource compiling peptide sequences with a potential immunomodulatory
activity. Fifteen out of the 300 hundred million peptides contained in the MAHMI
database were synthesized. These peptides were identified as being encrypted in
proteins produced by gut microbiota members, they do not contain cleavage points
for the major intestinal endoproteases and displayed high probability to have
immunomodulatory bioactivity. The bacterial peptides FR-16 and LR-17 encrypted in
proteins from Bifidobacterium longum DJ010A and Bifidobacterium fragilis YCH46
respectively, showed the higher immune modulation capability over human
peripheral blood mononuclear cells. Both peptides modulated the immune response
toward increases in the Th17 and decreases in the Th1 cell response, together
with an induction of IL-22 production. These results strongly suggest the
combined use of bioinformatics and in vitro tools as a first stage in the
screening of bioactive peptides encrypted in the human gut metaproteome.
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