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2017 ; 7
(1
): 11266
Nephropedia Template TP
gab.com Text
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English Wikipedia
Dynamic oropharyngeal and faecal microbiota during treatment in infants
hospitalized for bronchiolitis compared with age-matched healthy subjects
#MMPMID28900158
Hu Q
; Dai W
; Zhou Q
; Fu D
; Zheng Y
; Wang W
; Liu Y
; Yang Q
; Dai D
; Liu S
; Liu G
; Li S
; Wen F
Sci Rep
2017[Sep]; 7
(1
): 11266
PMID28900158
show ga
Bronchiolitis is one of the most severe diseases affecting infants worldwide. An
imbalanced oropharynx (OP) microbiota has been reported in infants hospitalized
with bronchiolitis; however, the microbiota dynamics in the OP and faeces during
therapy remain unexplored. In total, 27 infants who were hospitalized with
bronchiolitis were selected for this study, and sampling was conducted before
therapy and after clinical recovery. We also recruited 22 age-matched healthy
infants for this study. The faecal and OP microbiota diversity in the patients
was lower than that in the healthy children. The faecal microbiota (FM) in the
diseased children significantly differed from that in the healthy subjects and
contained accumulated Bacteroides and Streptococcus. The OP microbiota in both
the healthy and diseased infants was dominated by Streptococcus. After the
treatment, the FM and OP microbiota in the patients was comparable to that before
the treatment. This study may serve as an additional reference for future
bronchiolitis studies, and the "risk microbiota model" of clinically recovered
infants suggests an increased susceptibility to pathogen intrusion.