Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Biochem+Soc+Trans 2011 ; 39 (4): 1051-5 Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Functional roles of SPLUNC1 in innate immune response against gram negative bacteria #MMPMID21787346
Di Y
Biochem Soc Trans 2011[Aug]; 39 (4): 1051-5 PMID21787346show ga
Palate, lung, and nasal epithelium carcinoma associated (PLUNC) originally referred to one gene, but now has been extended to represent a gene family that consists of a number of genes with peptide sequence homologies and predicted structural similarities. PLUNC-like proteins display sequence homology to BPI, a 456-residue cationic protein produced by precursors of polymorphonuclear leukocytes, that has been shown to possess both bactericidal and LPS binding activities. The human PLUNC is also known as lung specific X protein (LUNX), nasopharyngeal carcinoma-related protein (NASG), and secretory protein in upper respiratory tracts (SPURT). The gene originally named PLUNC is now recognized as SPLUNC1. Its gene product SPLUNC1 is a secretory protein that is abundantly expressed in cells of the surface epithelium in the upper respiratory tracts and secretory glands in lung, and head and neck region. The functional role of SPLUNC1 in innate immunity has been suggested but not clearly defined. This paper will describe recent findings that support antimicrobial and anti-inflammatory functions of SPLUNC1 in gram negative bacteria induced respiratory infection.